Clustering of KOR PET images separates people with AUD into distinct responses to naltrexone

• Published in: Brain imaging and behavior Vol. 17; no. 3; pp. 367 - 371
• Main Authors: Hoye, Jocelyn, Key, Jose, de Laat, Bart, Cosgrove, Kelly P., Krishnan-Sarin, Suchitra, Papademetris, Xenophon, Morris, Evan D.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2023; Springer Nature B.V
• Subjects: Alcohol Drinking; Alcohol use; Alcoholism - diagnostic imaging; Alcoholism - drug therapy; Biomedical and Life Sciences; Biomedicine; Brief Report; Clustering; Drinking; Drinking behavior; Humans; Image acquisition; Magnetic Resonance Imaging; Naltrexone; Naltrexone - therapeutic use; Neostriatum; Neuropsychology; Neuroradiology; Neurosciences; Opioid receptors (type kappa); Positron emission; Positron-Emission Tomography - methods; Psychiatry; Receptors, Opioid, kappa; Reduction; Robustness; Sarin; Training; Variance analysis; Spectral clustering; Alcohol use disorder; Positron emission tomography; Small sample size; Machine learning; Kappa opioid receptor

Striatal kappa opioid receptor (KOR) availability in 48 subjects with Alcohol Use Disorder (AUD) was previously found to be associated with degree of drinking following a week of naltrexone treatment (de Laat et al.  Biological Psychiatry , 86 (11), 864-871, 2019 ). The purpose of the current study...