BI 1291583: a novel selective inhibitor of cathepsin C with superior in vivo profile for the treatment of bronchiectasis - Kreideweiss, Stefan; Schänzle, Gerhard; Schnapp, Gisela; Vintonyak, Viktor; Grundl, Marc A. (Inflammation research, 2023)
Keywords: Allergology; Biomedical and Life Sciences; Biomedicine; Bone marrow; Bronchiectasis; Bronchus; Cathepsins; Cell activation; Cells (biology); Dermatology; Dipeptidyl-peptidase I; Elastase; Enzymatic activity; Fluorescence; Immunology; Inflammatory diseases; Inhibition; Lavage; Leukocytes (neutrophilic); Lipopolysaccharides; Lung diseases; Lungs; Myelopoiesis; Neurology; Neutrophils; Original Research Paper; Pharmacology/Toxicology; Progenitor cells; Protease; Proteinase; Proteinase 3; Respiratory tract diseases; Rheumatology; Serine proteinase; Surface plasmon resonance; Cathepsin C inhibitor; Bronchiectasis; Preclinical; Neutrophil-derived serine protease activity