Non-coordinate Regulation of Endogenous Epithelial Sodium Channel (ENaC) Subunit Expression at the Apical Membrane of A6 Cells in Response to Various Transporting Conditions

• Published in: The Journal of biological chemistry Vol. 275; no. 51; pp. 39886 - 39893
• Main Authors: Weisz, Ora A., Wang, Jun-Min, Edinger, Robert S., Johnson, John P.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 22.12.2000; American Society for Biochemistry and Molecular Biology
• Subjects: Cell Membrane - metabolism; Epithelial Sodium Channels; HeLa Cells; Humans; Sodium Channels - immunology; Sodium Channels - metabolism

In many epithelial tissues in the body (e.g. kidney distal nephron, colon, airways) the rate of Na+ reabsorption is governed by the activity of the epithelial Na+ channel (ENaC). ENaC activity in turn is regulated by a number of factors including hormones, physiological conditions, and other ion cha...