Biometals and glycosylation in humans: Congenital disorders of glycosylation shed lights into the crucial role of Golgi manganese homeostasis

• Published in: Biochimica et biophysica acta. General subjects Vol. 1864; no. 10; p. 129674
• Main Authors: Foulquier, François, Legrand, Dominique
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2020; Elsevier
• Subjects: Animals; Antiporters - metabolism; Biochemistry, Molecular Biology; Biological Transport; Biometal homeostasis; calcium; Cation Transport Proteins - metabolism; cobalt; congenital abnormalities; Congenital disorders of glycosylation; Congenital Disorders of Glycosylation - metabolism; Congenital Disorders of Glycosylation - pathology; cytosol; extracellular space; Glycosylation; Golgi Apparatus - metabolism; Golgi Apparatus - pathology; Homeostasis; Humans; Life Sciences; magnesium; Manganese; Manganese - metabolism; metalloproteins; sugars; TMEM165; zinc; Glycosylation; Congenital disorders of glycosylation; Biometal homeostasis; Manganese; TMEM165

About half of the eukaryotic proteins bind biometals that participate in their structure and functions in virtually all physiological processes, including glycosylation. After reviewing the biological roles and transport mechanisms of calcium, magnesium, manganese, zinc and cobalt acting as cofactor...