Interaction of PTPIP51 with Tubulin, CGI-99 and Nuf2 During Cell Cycle Progression

Protein tyrosine phosphatase interacting protein 51 (PTPIP51), also known as regulator of microtubule dynamics protein 3, was identified as an in vitro and in vivo interaction partner of CGI-99 and Nuf-2. PTPIP51 mRNA is expressed in all stages of the cell cycle; it is highly expressed six hours pos...

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Published inBiomolecules (Basel, Switzerland) Vol. 2; no. 1; pp. 122 - 142
Main Authors Brobeil, Alexander, Graf, Michaela, Eiber, Moritz, Wimmer, Monika
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 23.02.2012
MDPI
Subjects
cell cycle
CGI-99
EGFR
FAM82A2
FAM82C
microtubule
mitosis
Nuf-2
PTPIP51
RMD-3
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Abstract Protein tyrosine phosphatase interacting protein 51 (PTPIP51), also known as regulator of microtubule dynamics protein 3, was identified as an in vitro and in vivo interaction partner of CGI-99 and Nuf-2. PTPIP51 mRNA is expressed in all stages of the cell cycle; it is highly expressed six hours post-nocodazole treatment and minimally expressed one hour post-nocodazole treatment. Recent investigations located PTPIP51 protein at the equatorial plate. This study reports the localization of the PTPIP51/CGI-99 and the PTPIP51/Nuf-2 complex at the equatorial region during mitosis. Moreover, Duolink proximity ligation assays revealed an association of PTPIP51 with the microtubular cytoskeleton and the spindle apparatus. High amounts of phosphorylated PTPIP51 associated with the spindle poles was seen by confocal microscopy. In parallel a strong interaction of PTPIP51 with the epidermal growth factor receptor phosphorylating PTPIP51 at the tyrosine 176 residue was seen. In the M/G1 transition a high level of interaction between PTPIP51 and PTP1B was registered, thus restoring the interaction of PTPIP51 and Raf-1, depleted in mitotic cells. Summarizing these new facts, we conclude that PTPIP51 is necessary for normal mitotic processes, impacting on chromosomal division and control of the MAPK pathway activity.
AbstractList Protein tyrosine phosphatase interacting protein 51 (PTPIP51), also known as regulator of microtubule dynamics protein 3, was identified as an in vitro and in vivo interaction partner of CGI-99 and Nuf-2. PTPIP51 mRNA is expressed in all stages of the cell cycle; it is highly expressed six hours post-nocodazole treatment and minimally expressed one hour post-nocodazole treatment. Recent investigations located PTPIP51 protein at the equatorial plate. This study reports the localization of the PTPIP51/CGI-99 and the PTPIP51/Nuf-2 complex at the equatorial region during mitosis. Moreover, Duolink proximity ligation assays revealed an association of PTPIP51 with the microtubular cytoskeleton and the spindle apparatus. High amounts of phosphorylated PTPIP51 associated with the spindle poles was seen by confocal microscopy. In parallel a strong interaction of PTPIP51 with the epidermal growth factor receptor phosphorylating PTPIP51 at the tyrosine 176 residue was seen. In the M/G1 transition a high level of interaction between PTPIP51 and PTP1B was registered, thus restoring the interaction of PTPIP51 and Raf-1, depleted in mitotic cells. Summarizing these new facts, we conclude that PTPIP51 is necessary for normal mitotic processes, impacting on chromosomal division and control of the MAPK pathway activity.
Protein tyrosine phosphatase interacting protein 51 (PTPIP51), also known as regulator of microtubule dynamics protein 3, was identified as an in vitro and in vivo interaction partner of CGI-99 and Nuf-2. PTPIP51 mRNA is expressed in all stages of the cell cycle; it is highly expressed six hours post-nocodazole treatment and minimally expressed one hour post-nocodazole treatment. Recent investigations located PTPIP51 protein at the equatorial plate. This study reports the localization of the PTPIP51/CGI-99 and the PTPIP51/Nuf-2 complex at the equatorial region during mitosis. Moreover, Duolink proximity ligation assays revealed an association of PTPIP51 with the microtubular cytoskeleton and the spindle apparatus. High amounts of phosphorylated PTPIP51 associated with the spindle poles was seen by confocal microscopy. In parallel a strong interaction of PTPIP51 with the epidermal growth factor receptor phosphorylating PTPIP51 at the tyrosine 176 residue was seen. In the M/G1 transition a high level of interaction between PTPIP51 and PTP1B was registered, thus restoring the interaction of PTPIP51 and Raf-1, depleted in mitotic cells. Summarizing these new facts, we conclude that PTPIP51 is necessary for normal mitotic processes, impacting on chromosomal division and control of the MAPK pathway activity.
Author Eiber, Moritz
Graf, Michaela
Wimmer, Monika
Brobeil, Alexander
AuthorAffiliation Institute of Anatomy and Cell Biology, Justus-Liebig-University, 35392 Giessen, Germany; Email: michaela.graf@anatomie.med.uni-giessen.de (M.G.); moritz.eiber@med.uni-giessen.de (M.E.); monika.wimmer@anatomie.med.uni-giessen.de (M.W.)
AuthorAffiliation_xml – name: Institute of Anatomy and Cell Biology, Justus-Liebig-University, 35392 Giessen, Germany; Email: michaela.graf@anatomie.med.uni-giessen.de (M.G.); moritz.eiber@med.uni-giessen.de (M.E.); monika.wimmer@anatomie.med.uni-giessen.de (M.W.)
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  organization: Institute of Anatomy and Cell Biology, Justus-Liebig-University, 35392 Giessen, Germany. monika.wimmer@anatomie.med.uni-giessen.de
BackLink https://www.ncbi.nlm.nih.gov/pubmed/24970130$$D View this record in MEDLINE/PubMed
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Snippet Protein tyrosine phosphatase interacting protein 51 (PTPIP51), also known as regulator of microtubule dynamics protein 3, was identified as an in vitro and in...
Protein tyrosine phosphatase interacting protein 51 (PTPIP51), also known as regulator of microtubule dynamics protein 3, was identified as an in vitro and in...
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StartPage 122
SubjectTerms cell cycle
CGI-99
EGFR
FAM82A2
FAM82C
microtubule
mitosis
Nuf-2
PTPIP51
RMD-3
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Title Interaction of PTPIP51 with Tubulin, CGI-99 and Nuf2 During Cell Cycle Progression
URI https://www.ncbi.nlm.nih.gov/pubmed/24970130
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https://pubmed.ncbi.nlm.nih.gov/PMC4030868
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