Influence of PTGS1, PTGFR, and MRP4 genetic variants on intraocular pressure response to latanoprost in Chinese primary open-angle glaucoma patients

• Published in: European journal of clinical pharmacology Vol. 71; no. 1; pp. 43 - 50
• Main Authors: Gao, Li-chen, Wang, Di, Liu, Fang-qun, Huang, Zheng-yu, Huang, Hong-guang, Wang, Gui-hua, Chen, Xi, Shi, Qun-zhi, Hong, Li, Wu, Li-ping, Tang, Jie
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2015; Springer Nature B.V
• Subjects: Adult; Antihypertensive Agents - pharmacology; Asian Continental Ancestry Group - genetics; Biomedical and Life Sciences; Biomedicine; Blood pressure; Cyclooxygenase 1 - genetics; Drug therapy; Female; Glaucoma; Glaucoma, Open-Angle - genetics; Glaucoma, Open-Angle - physiopathology; Humans; Intraocular Pressure - drug effects; Latanoprost; Male; Middle Aged; Multidrug Resistance-Associated Proteins - genetics; Patients; Pharmacogenetics; Pharmacology/Toxicology; Polymorphism, Single Nucleotide; Prostaglandins F, Synthetic - pharmacology; Receptors, Prostaglandin - genetics; Glaucoma; Pharmacogenetics; Latanoprost; Intraocular pressure

Purpose The purpose of this study is to evaluate the association between variants in prostaglandin-endoperoxide synthase 1 ( PTGS1 ), prostaglandin F (2α) receptor ( PTGFR ), and multidrug resistance protein 4 ( MRP4 ) genes and intraocular pressure (IOP) response to latanoprost in Chinese patients...