Inhibition of constitutive aryl hydrocarbon receptor (AhR) signaling attenuates androgen independent signaling and growth in (C4-2) prostate cancer cells

• Published in: Biochemical pharmacology Vol. 85; no. 6; pp. 753 - 762
• Main Authors: Tran, Cindy, Richmond, Oliver, Aaron, LaTayia, Powell, Joann B.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 15.03.2013
• Subjects: AhR; Androgen receptor; androgen receptors; Androgens - physiology; Base Sequence; Blotting, Western; carcinogens; Cell Division; Cell Line, Tumor; Cell Proliferation; Dioxin; DNA Primers; drugs; enzymes; genes; Humans; Immunohistochemistry; Male; metabolism; polycyclic aromatic hydrocarbons; Progression; prostatic neoplasms; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; Receptors, Aryl Hydrocarbon - metabolism; Reverse Transcriptase Polymerase Chain Reaction; RNA; Signal Transduction; TCDD; toxicity; transcription factors; Progression; TCDD; AhR; Dioxin; Androgen receptor

The aryl hydrocarbon receptor is a member of the basic-helix-loop-helix family of transcription factors. AhR mediates the biochemical and toxic effects of a number of polyaromatic hydrocarbons such as 2,3,7,8,-tetrachloro-dibenzo-p-dioxin (TCDD). AhR is widely known for regulating the transcription...