TIMP-3 -1296 T>C and TIMP-4 -55 T>C gene polymorphisms play a role in the susceptibility of hepatocellular carcinoma among women

• Published in: Tumor biology Vol. 35; no. 9; pp. 8999 - 9007
• Main Authors: Tsai, Hsiu-Ting, Hsieh, Ming-Ju, Chiou, Hui-Ling, Lee, Hsiang-Lin, Hsin, Min-Chieh, Liou, Yi-Sheng, Yang, Chen-Chieh, Yang, Shun-Fa, Kuo, Wu-Hsien
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.09.2014; Springer Nature B.V
• Subjects: Analysis of Variance; Asian People - genetics; Biomarkers; Biomedical and Life Sciences; Biomedicine; Cancer Research; Carcinoma, Hepatocellular - ethnology; Carcinoma, Hepatocellular - genetics; Case-Control Studies; Cellular biology; Female; Gene Frequency; Genetic Predisposition to Disease - ethnology; Genetic Predisposition to Disease - genetics; Genetics; Genotype; Hepatology; Humans; Linkage Disequilibrium; Liver Neoplasms - ethnology; Liver Neoplasms - genetics; Male; Middle Aged; Polymorphism; Polymorphism, Single Nucleotide; Research Article; Risk Factors; Sex Factors; Taiwan; Tissue Inhibitor of Metalloproteinase-3 - genetics; Tissue Inhibitor of Metalloproteinase-4; Tissue Inhibitor of Metalloproteinases - genetics; Womens health; Taiwan; Hepatocellular carcinoma; Single nucleotide polymorphism

The purpose of this study was to investigate genetic impact of TIMP-3 -1296 T>C (rs9619311) and TIMP-4 -55 T>C (rs3755724) gene polymorphisms on the susceptibility and clinicopathological characteristics of hepatocellular carcinoma (HCC). A total of 759 subjects, including 530 healthy controls...