TIMP-3 -1296 T>C and TIMP-4 -55 T>C gene polymorphisms play a role in the susceptibility of hepatocellular carcinoma among women

The purpose of this study was to investigate genetic impact of TIMP-3 -1296 T>C (rs9619311) and TIMP-4 -55 T>C (rs3755724) gene polymorphisms on the susceptibility and clinicopathological characteristics of hepatocellular carcinoma (HCC). A total of 759 subjects, including 530 healthy controls...

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Published inTumor biology Vol. 35; no. 9; pp. 8999 - 9007
Main Authors Tsai, Hsiu-Ting, Hsieh, Ming-Ju, Chiou, Hui-Ling, Lee, Hsiang-Lin, Hsin, Min-Chieh, Liou, Yi-Sheng, Yang, Chen-Chieh, Yang, Shun-Fa, Kuo, Wu-Hsien
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.09.2014
Springer Nature B.V
Subjects
Analysis of Variance
Asian People - genetics
Biomarkers
Biomedical and Life Sciences
Biomedicine
Cancer Research
Carcinoma, Hepatocellular - ethnology
Carcinoma, Hepatocellular - genetics
Case-Control Studies
Cellular biology
Female
Gene Frequency
Genetic Predisposition to Disease - ethnology
Genetic Predisposition to Disease - genetics
Genetics
Genotype
Hepatology
Humans
Linkage Disequilibrium
Liver Neoplasms - ethnology
Liver Neoplasms - genetics
Male
Middle Aged
Polymorphism
Polymorphism, Single Nucleotide
Research Article
Risk Factors
Sex Factors
Taiwan
Tissue Inhibitor of Metalloproteinase-3 - genetics
Tissue Inhibitor of Metalloproteinase-4
Tissue Inhibitor of Metalloproteinases - genetics
Womens health
Taiwan
Hepatocellular carcinoma
Single nucleotide polymorphism
Online AccessGet full text
ISSN1010-4283
1423-0380
1423-0380
DOI10.1007/s13277-014-2170-z

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Abstract The purpose of this study was to investigate genetic impact of TIMP-3 -1296 T>C (rs9619311) and TIMP-4 -55 T>C (rs3755724) gene polymorphisms on the susceptibility and clinicopathological characteristics of hepatocellular carcinoma (HCC). A total of 759 subjects, including 530 healthy controls and 229 patients with hepatocellular carcinoma, were recruited in this study. Allelic discrimination of TIMP-3 -1296 T>C (rs9619311) and TIMP-4 -55 T>C (rs3755724) polymorphisms was assessed with the ABI StepOne™ Real-Time PCR System. Among women group, individuals with TC or CC alleles of TIMP-3 -1296 T>C gene polymorphism protected against HCC (AOR = 0.35, 95% confidence interval (CI) = 0.12–0.97; p  = 0.04) compared to individuals with TT alleles, after adjusting for other confounders. Also, women with TC alleles and with TC or CC alleles of TIMP-4 -55 T>C polymorphisms had a 2.52-fold risk (95%CI = 1.23–5.13; p  = 0.01) and 2.47-fold risk (95%CI = 1.26–4.87; p  = 0.008) of developing HCC compared to individuals with TT alleles, after adjusting for other confounders. There was no synergistic effect between gene polymorphism and environmental risk factors, including tobacco and alcohol consumptions and clinical statuses of HCC as well as serum expression of liver-related clinicopathological markers. In conclusion, gene polymorphisms of TIMP-3 -1296 T>C (rs9619311) and TIMP-4 -55 T>C (rs3755724) play a role in the susceptibility of HCC among Taiwan women.
AbstractList The purpose of this study was to investigate genetic impact of TIMP-3 -1296 T>C (rs9619311) and TIMP-4 -55 T>C (rs3755724) gene polymorphisms on the susceptibility and clinicopathological characteristics of hepatocellular carcinoma (HCC). A total of 759 subjects, including 530 healthy controls and 229 patients with hepatocellular carcinoma, were recruited in this study. Allelic discrimination of TIMP-3 -1296 T>C (rs9619311) and TIMP-4 -55 T>C (rs3755724) polymorphisms was assessed with the ABI StepOne(TM) Real-Time PCR System. Among women group, individuals with TC or CC alleles of TIMP-3 -1296 T>C gene polymorphism protected against HCC (AOR=0.35, 95% confidence interval (CI)=0.12-0.97; p=0.04) compared to individuals with TT alleles, after adjusting for other confounders. Also, women with TC alleles and with TC or CC alleles of TIMP-4 -55 T>C polymorphisms had a 2.52-fold risk (95%CI=1.23-5.13; p=0.01) and 2.47-fold risk (95%CI=1.26-4.87; p=0.008) of developing HCC compared to individuals with TT alleles, after adjusting for other confounders. There was no synergistic effect between gene polymorphism and environmental risk factors, including tobacco and alcohol consumptions and clinical statuses of HCC as well as serum expression of liver-related clinicopathological markers. In conclusion, gene polymorphisms of TIMP-3 -1296 T>C (rs9619311) and TIMP-4 -55 T>C (rs3755724) play a role in the susceptibility of HCC among Taiwan women.
The purpose of this study was to investigate genetic impact of TIMP-3 -1296 T>C (rs9619311) and TIMP-4 -55 T>C (rs3755724) gene polymorphisms on the susceptibility and clinicopathological characteristics of hepatocellular carcinoma (HCC). A total of 759 subjects, including 530 healthy controls and 229 patients with hepatocellular carcinoma, were recruited in this study. Allelic discrimination of TIMP-3 -1296 T>C (rs9619311) and TIMP-4 -55 T>C (rs3755724) polymorphisms was assessed with the ABI StepOne™ Real-Time PCR System. Among women group, individuals with TC or CC alleles of TIMP-3 -1296 T>C gene polymorphism protected against HCC (AOR = 0.35, 95% confidence interval (CI) = 0.12-0.97; p = 0.04) compared to individuals with TT alleles, after adjusting for other confounders. Also, women with TC alleles and with TC or CC alleles of TIMP-4 -55 T>C polymorphisms had a 2.52-fold risk (95%CI = 1.23-5.13; p = 0.01) and 2.47-fold risk (95%CI = 1.26-4.87; p = 0.008) of developing HCC compared to individuals with TT alleles, after adjusting for other confounders. There was no synergistic effect between gene polymorphism and environmental risk factors, including tobacco and alcohol consumptions and clinical statuses of HCC as well as serum expression of liver-related clinicopathological markers. In conclusion, gene polymorphisms of TIMP-3 -1296 T>C (rs9619311) and TIMP-4 -55 T>C (rs3755724) play a role in the susceptibility of HCC among Taiwan women.
The purpose of this study was to investigate genetic impact of TIMP-3 -1296 T>C (rs9619311) and TIMP-4 -55 T>C (rs3755724) gene polymorphisms on the susceptibility and clinicopathological characteristics of hepatocellular carcinoma (HCC). A total of 759 subjects, including 530 healthy controls and 229 patients with hepatocellular carcinoma, were recruited in this study. Allelic discrimination of TIMP-3 -1296 T>C (rs9619311) and TIMP-4 -55 T>C (rs3755724) polymorphisms was assessed with the ABI StepOne™ Real-Time PCR System. Among women group, individuals with TC or CC alleles of TIMP-3 -1296 T>C gene polymorphism protected against HCC (AOR = 0.35, 95% confidence interval (CI) = 0.12-0.97; p = 0.04) compared to individuals with TT alleles, after adjusting for other confounders. Also, women with TC alleles and with TC or CC alleles of TIMP-4 -55 T>C polymorphisms had a 2.52-fold risk (95%CI = 1.23-5.13; p = 0.01) and 2.47-fold risk (95%CI = 1.26-4.87; p = 0.008) of developing HCC compared to individuals with TT alleles, after adjusting for other confounders. There was no synergistic effect between gene polymorphism and environmental risk factors, including tobacco and alcohol consumptions and clinical statuses of HCC as well as serum expression of liver-related clinicopathological markers. In conclusion, gene polymorphisms of TIMP-3 -1296 T>C (rs9619311) and TIMP-4 -55 T>C (rs3755724) play a role in the susceptibility of HCC among Taiwan women.The purpose of this study was to investigate genetic impact of TIMP-3 -1296 T>C (rs9619311) and TIMP-4 -55 T>C (rs3755724) gene polymorphisms on the susceptibility and clinicopathological characteristics of hepatocellular carcinoma (HCC). A total of 759 subjects, including 530 healthy controls and 229 patients with hepatocellular carcinoma, were recruited in this study. Allelic discrimination of TIMP-3 -1296 T>C (rs9619311) and TIMP-4 -55 T>C (rs3755724) polymorphisms was assessed with the ABI StepOne™ Real-Time PCR System. Among women group, individuals with TC or CC alleles of TIMP-3 -1296 T>C gene polymorphism protected against HCC (AOR = 0.35, 95% confidence interval (CI) = 0.12-0.97; p = 0.04) compared to individuals with TT alleles, after adjusting for other confounders. Also, women with TC alleles and with TC or CC alleles of TIMP-4 -55 T>C polymorphisms had a 2.52-fold risk (95%CI = 1.23-5.13; p = 0.01) and 2.47-fold risk (95%CI = 1.26-4.87; p = 0.008) of developing HCC compared to individuals with TT alleles, after adjusting for other confounders. There was no synergistic effect between gene polymorphism and environmental risk factors, including tobacco and alcohol consumptions and clinical statuses of HCC as well as serum expression of liver-related clinicopathological markers. In conclusion, gene polymorphisms of TIMP-3 -1296 T>C (rs9619311) and TIMP-4 -55 T>C (rs3755724) play a role in the susceptibility of HCC among Taiwan women.
The purpose of this study was to investigate genetic impact of TIMP-3 -1296 T>C (rs9619311) and TIMP-4 -55 T>C (rs3755724) gene polymorphisms on the susceptibility and clinicopathological characteristics of hepatocellular carcinoma (HCC). A total of 759 subjects, including 530 healthy controls and 229 patients with hepatocellular carcinoma, were recruited in this study. Allelic discrimination of TIMP-3 -1296 T>C (rs9619311) and TIMP-4 -55 T>C (rs3755724) polymorphisms was assessed with the ABI StepOne(TM) Real-Time PCR System. Among women group, individuals with TC or CC alleles of TIMP-3 -1296 T>C gene polymorphism protected against HCC (AOR=0.35, 95% confidence interval (CI)=0.12-0.97; p=0.04) compared to individuals with TT alleles, after adjusting for other confounders. Also, women with TC alleles and with TC or CC alleles of TIMP-4 -55 T>C polymorphisms had a 2.52-fold risk (95%CI=1.23-5.13; p=0.01) and 2.47-fold risk (95%CI=1.26-4.87; p=0.008) of developing HCC compared to individuals with TT alleles, after adjusting for other confounders. There was no synergistic effect between gene polymorphism and environmental risk factors, including tobacco and alcohol consumptions and clinical statuses of HCC as well as serum expression of liver-related clinicopathological markers. In conclusion, gene polymorphisms of TIMP-3 -1296 T>C (rs9619311) and TIMP-4 -55 T>C (rs3755724) play a role in the susceptibility of HCC among Taiwan women.[PUBLICATION ABSTRACT]
The purpose of this study was to investigate genetic impact of TIMP-3 -1296 T>C (rs9619311) and TIMP-4 -55 T>C (rs3755724) gene polymorphisms on the susceptibility and clinicopathological characteristics of hepatocellular carcinoma (HCC). A total of 759 subjects, including 530 healthy controls and 229 patients with hepatocellular carcinoma, were recruited in this study. Allelic discrimination of TIMP-3 -1296 T>C (rs9619311) and TIMP-4 -55 T>C (rs3755724) polymorphisms was assessed with the ABI StepOne™ Real-Time PCR System. Among women group, individuals with TC or CC alleles of TIMP-3 -1296 T>C gene polymorphism protected against HCC (AOR = 0.35, 95% confidence interval (CI) = 0.12–0.97; p  = 0.04) compared to individuals with TT alleles, after adjusting for other confounders. Also, women with TC alleles and with TC or CC alleles of TIMP-4 -55 T>C polymorphisms had a 2.52-fold risk (95%CI = 1.23–5.13; p  = 0.01) and 2.47-fold risk (95%CI = 1.26–4.87; p  = 0.008) of developing HCC compared to individuals with TT alleles, after adjusting for other confounders. There was no synergistic effect between gene polymorphism and environmental risk factors, including tobacco and alcohol consumptions and clinical statuses of HCC as well as serum expression of liver-related clinicopathological markers. In conclusion, gene polymorphisms of TIMP-3 -1296 T>C (rs9619311) and TIMP-4 -55 T>C (rs3755724) play a role in the susceptibility of HCC among Taiwan women.
Author Liou, Yi-Sheng
Kuo, Wu-Hsien
Hsieh, Ming-Ju
Yang, Shun-Fa
Chiou, Hui-Ling
Tsai, Hsiu-Ting
Lee, Hsiang-Lin
Hsin, Min-Chieh
Yang, Chen-Chieh
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  givenname: Hsiu-Ting
  surname: Tsai
  fullname: Tsai, Hsiu-Ting
  organization: School of Nursing, College of Nursing, Taipei Medical University, School of Nursing, Chung Shan Medical University
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  givenname: Ming-Ju
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  fullname: Hsieh, Ming-Ju
  organization: Cancer Research Center, Changhua Christian Hospital, Institute of Medicine, Chung Shan Medical University
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/24903383$$D View this record in MEDLINE/PubMed
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Issue 9
Keywords Hepatocellular carcinoma
Single nucleotide polymorphism
Language English
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PublicationCentury 2000
PublicationDate 2014-09-01
PublicationDateYYYYMMDD 2014-09-01
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  year: 2014
  text: 2014-09-01
  day: 01
PublicationDecade 2010
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PublicationSubtitle Tumor Markers, Tumor Targeting and Translational Cancer Research
PublicationTitle Tumor biology
PublicationTitleAbbrev Tumor Biol
PublicationTitleAlternate Tumour Biol
PublicationYear 2014
Publisher Springer Netherlands
Springer Nature B.V
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References YuYLWeiCWChenYLChenMHYiangGTImmunotherapy of breast cancer by single delivery with raav2-mediated interleukin-15 expressionInt J Oncol201036365701:CAS:528:DC%2BC3cXitF2gtrg%3D10.3892/ijo_0000060320043070
HaoKLukJMLeeNPMaoMZhangCFergusonMDPredicting prognosis in hepatocellular carcinoma after curative surgery with common clinicopathologic parametersBMC Cancer20099389278583510.1186/1471-2407-9-38919886989
MenghiniRMeniniSAmorusoRFiorentinoLCasagrandeVMarzanoVTissue inhibitor of metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in miceGastroenterology2009136663721:CAS:528:DC%2BD1MXislOhtbg%3D10.1053/j.gastro.2008.10.07919027012e4
YuMWChangHCChangSCLiawYFLinSMLiuCJRole of reproductive factors in hepatocellular carcinoma: impact on hepatitis b- and c-related riskHepatology200338139340014647050
SeongJChallenge and hope in radiotherapy of hepatocellular carcinomaYonsei Med J20095060112276823210.3349/ymj.2009.50.5.60119881961
Centers for Disease Control, Taiwan http://www.cdc.gov.tw 2007
RiddickACShuklaCJPenningtonCJBassRNuttallRKHoganAIdentification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissuesBr J Cancer20059221718023618191:CAS:528:DC%2BD2MXltVygtLs%3D10.1038/sj.bjc.660263015928670
Celebiler CavusogluAKilicYSaydamSCandaTBaskanZSevincAIPredicting invasive phenotype with CDH1, CDH13, CD44, and TIMP3 gene expression in primary breast cancerCancer Sci20091002341510.1111/j.1349-7006.2009.01333.x19799609
WangMLiuYEGreeneJShengSFuchsARosenEMInhibition of tumor growth and metastasis of human breast cancer cells transfected with tissue inhibitor of metalloproteinase 4Oncogene1997142767741:CAS:528:DyaK2sXktF2nt7c%3D10.1038/sj.onc.12012459190892
HishidaMNomotoSInokawaYHayashiMKandaMOkamuraYEstrogen receptor 1 gene as a tumor suppressor gene in hepatocellular carcinoma detected by triple-combination array analysisInt J Oncol20134388941:CAS:528:DC%2BC3sXhtFOltLrM23695389
YiangGTHarnHJYuYLHuSCHungYTHsiehCJImmunotherapy: rAAV2 expressing interleukin-15 inhibits Hela cell tumor growth in miceJ Biomed Sci20091647268743210.1186/1423-0127-16-4719422685
WildARamaswamyALangerPCelikIFendrichVChaloupkaBFrequent methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene in pancreatic endocrine tumorsJ Clin Endocrinol Metab2003881367731:CAS:528:DC%2BD3sXit1ensb4%3D10.1210/jc.2002-02102712629131
TranPLVigneronJPPericatDDuboisSCazalsDHervyMGene therapy for hepatocellular carcinoma using non-viral vectors composed of bis guanidinium-tren-cholesterol and plasmids encoding the tissue inhibitors of metalloproteinases TIMP-2 and TIMP-3Cancer Gene Ther200310435441:CAS:528:DC%2BD3sXjvF2lu7w%3D10.1038/sj.cgt.770059212768188
LeiHHemminkiKAltieriAJohanssonREnquistKHallmansGPromoter polymorphisms in matrix metalloproteinases and their inhibitors: few associations with breast cancer susceptibility and progressionBreast Cancer Res Treat20071036191:CAS:528:DC%2BD2sXksFans7w%3D10.1007/s10549-006-9345-217033924
OgataTShibamuraHTrompGSinhaMGoddardKASakalihasanNGenetic analysis of polymorphisms in biologically relevant candidate genes in patients with abdominal aortic aneurysmsJ Vasc Surg200541103642124949910.1016/j.jvs.2005.02.02015944607
NakamuraMIshidaEShimadaKKishiMNakaseHSakakiTFrequent LOH on 22q12.3 and TIMP-3 inactivation occur in the progression to secondary glioblastomasLab Investig200585165751:CAS:528:DC%2BD2MXhtFWgtLo%3D10.1038/labinvest.370022315592495
OkitaKManagement of hepatocellular carcinoma in JapanJ Gastroenterol200641100610.1007/s00535-005-1763-016568368
HassanZKDaghestaniMHCurcumin effect on MMPs and TIMPs genes in a breast cancer cell lineAsian Pac J Cancer Prev20121332596410.7314/APJCP.2012.13.7.325922994744
DammannRStrunnikovaMSchagdarsurenginURastetterMPapritzMHattenhorstUECpG island methylation and expression of tumour-associated genes in lung carcinomaEur J Cancer2005411223361:CAS:528:DC%2BD2MXks1Gjt74%3D10.1016/j.ejca.2005.02.02015911247
BanJYYoonKLKimSKKangSChungJHPromoter polymorphism (rs3755724, −55c/t) of tissue inhibitor of metalloproteinase 4 (TIMP4) as a risk factor for Kawasaki disease with coronary artery lesions in a Korean populationPediatr Cardiol200930331510.1007/s00246-008-9341-x19048177
PilkaRObornaILichnovskyVHavelkaPFingerovaHErikssonPEndometrial expression of the estrogen-sensitive genes MMP-26 and TIMP-4 is altered by a substitution protocol without down-regulation in IVF patientsHum Reprod2006213146561:CAS:528:DC%2BD28XhtlChtLfJ10.1093/humrep/del18017012332
HeYCuiYWangWGuJGuoSMaKHypomethylation of the hsa-mir-191 locus causes high expression of hsa-mir-191 and promotes the epithelial-to-mesenchymal transition in hepatocellular carcinomaNeoplasia2011138415331822761:CAS:528:DC%2BC3MXhsF2isbvJ10.1593/neo.1169821969817
WangBHsuSHMajumderSKutayHHuangWJacobSTTGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3Oncogene20102917879728457431:CAS:528:DC%2BD1MXhsFyhsLvO10.1038/onc.2009.46820023698
WieczorekEReszkaEJablonowskiZJablonskaEBeata KrolMGrzegorczykAGenetic polymorphisms in matrix metalloproteinases (MMPs) and tissue inhibitors of MPs (TIMPs), and bladder cancer susceptibilityBJU Int20131121207141:CAS:528:DC%2BC3sXhslCgur%2FO10.1111/bju.1223023819551
XiangYZhangXLiQXuJZhouXWangTPromoter hypomethylation of TIMP3 is associated with pre-eclampsia in a Chinese populationMol Hum Reprod20131915391:CAS:528:DC%2BC3sXjtF2kt78%3D10.1093/molehr/gas05423172037
TsaiHTYangSFChenDRChanSECCL5-28, CCL5-403, and CCR5 genetic polymorphisms and their synergic effect with alcohol and tobacco consumptions increase susceptibility to hepatocellular carcinomaMed Oncol201229277191:CAS:528:DC%2BC38XhsVyqtL7L10.1007/s12032-012-0189-922374185
BruixJTreatment of hepatocellular carcinomaHepatology199725259621:STN:280:DyaK2s7nsVWqtQ%3D%3D10.1002/hep.5102502019021931
YuanYWangJLiJWangLLiMYangZFrequent epigenetic inactivation of spleen tyrosine kinase gene in human hepatocellular carcinomaClin Cancer Res20061266879518321521:CAS:528:DC%2BD28Xht1elsL%2FI10.1158/1078-0432.CCR-06-092117121887
YehCBTsaiHTChenYCKuoWHChenTYHsiehYHGenetic polymorphism of CCR2-64I increased the susceptibility of hepatocellular carcinomaJ Surg Oncol2010102264701:CAS:528:DC%2BC3cXhtFOhsrvM10.1002/jso.2162320740585
PetersonNBBeeghly-FadielAGaoYTLongJCaiQShuXOPolymorphisms in tissue inhibitors of metalloproteinases-2 and −3 and breast cancer susceptibility and survivalInt J Cancer20091258445027459951:CAS:528:DC%2BD1MXnsFeltL4%3D10.1002/ijc.2440519431211
PilkaRDomanskiHHanssonSErikssonPCasslenBEndometrial TIMP-4 mRNA is high at midcycle and in hyperplasia, but down-regulated in malignant tumours. Coordinated expression with mmp-26Mol Hum Reprod200410641501:CAS:528:DC%2BD2cXntFamsLg%3D10.1093/molehr/gah09215273280
LiuWHYehSHLuCCYuSLChenHYLinCYMicrorna-18a prevents estrogen receptor-alpha expression, promoting proliferation of hepatocellular carcinoma cellsGastroenterology2009136683931:CAS:528:DC%2BD1MXislOhtbY%3D10.1053/j.gastro.2008.10.02919027010
ShenBChuESZhaoGManKWuCWChengJTPPARgamma inhibits hepatocellular carcinoma metastases in vitro and in miceBr J Cancer201210614869433418691:CAS:528:DC%2BC38Xmt1Ghu74%3D10.1038/bjc.2012.13022472882
WuCSYenCJChouRHLiSTHuangWCRenCTCancer-associated carbohydrate antigens as potential biomarkers for hepatocellular carcinomaPLoS ONE20127e3946633966211:CAS:528:DC%2BC38XhtVyisrjE10.1371/journal.pone.003946622808038
ChenYLTsengHSKuoWHYangSFChenDRTsaiHTGlutathione s-transferase p1 (GSTP1) gene polymorphism increases age-related susceptibility to hepatocellular carcinomaBMC Med Genet20101146285159310.1186/1471-2350-11-4620331903
Department of Health: Republic of china: “Health promotion administration, ministry of health and welfare” department of health. Taipei 2013
KimJRKimCHAssociation of a high activity of matrix metalloproteinase-9 to low levels of tissue inhibitors of metalloproteinase-1 and −3 in human hepatitis b-viral hepatoma cellsInt J Biochem Cell Biol20043622933061:CAS:528:DC%2BD2cXmslOitbo%3D10.1016/j.biocel.2004.04.02215313474
El HajjECEl HajjMCVoloshenyukTGMoutonAJKhoutorovaEMolinaPEAlcohol modulation of cardiac matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs favors collagen accumulationAlcohol Clin Exp Res20143844856408081210.1111/acer.1223924033327
YL Yu (2170_CR20) 2010; 36
Y Yuan (2170_CR13) 2006; 12
YL Chen (2170_CR37) 2010; 11
R Menghini (2170_CR7) 2009; 136
T Ogata (2170_CR17) 2005; 41
JR Kim (2170_CR6) 2004; 36
J Seong (2170_CR5) 2009; 50
NB Peterson (2170_CR24) 2009; 125
2170_CR1
J Bruix (2170_CR2) 1997; 25
GT Yiang (2170_CR22) 2009; 16
JY Ban (2170_CR18) 2009; 30
K Okita (2170_CR3) 2006; 41
ZK Hassan (2170_CR8) 2012; 13
M Nakamura (2170_CR28) 2005; 85
EC Hajj El (2170_CR35) 2014; 38
Y He (2170_CR11) 2011; 13
AC Riddick (2170_CR14) 2005; 92
PL Tran (2170_CR9) 2003; 10
R Dammann (2170_CR15) 2005; 41
R Pilka (2170_CR34) 2006; 21
WH Liu (2170_CR30) 2009; 136
M Wang (2170_CR16) 1997; 14
E Wieczorek (2170_CR25) 2013; 112
B Wang (2170_CR10) 2010; 29
MW Yu (2170_CR29) 2003; 38
H Lei (2170_CR23) 2007; 103
Y Xiang (2170_CR26) 2013; 19
HT Tsai (2170_CR36) 2012; 29
B Shen (2170_CR12) 2012; 106
2170_CR19
CS Wu (2170_CR21) 2012; 7
CB Yeh (2170_CR38) 2010; 102
K Hao (2170_CR4) 2009; 9
M Hishida (2170_CR31) 2013; 43
A Celebiler Cavusoglu (2170_CR32) 2009; 100
A Wild (2170_CR27) 2003; 88
R Pilka (2170_CR33) 2004; 10
References_xml – reference: TsaiHTYangSFChenDRChanSECCL5-28, CCL5-403, and CCR5 genetic polymorphisms and their synergic effect with alcohol and tobacco consumptions increase susceptibility to hepatocellular carcinomaMed Oncol201229277191:CAS:528:DC%2BC38XhsVyqtL7L10.1007/s12032-012-0189-922374185
– reference: KimJRKimCHAssociation of a high activity of matrix metalloproteinase-9 to low levels of tissue inhibitors of metalloproteinase-1 and −3 in human hepatitis b-viral hepatoma cellsInt J Biochem Cell Biol20043622933061:CAS:528:DC%2BD2cXmslOitbo%3D10.1016/j.biocel.2004.04.02215313474
– reference: XiangYZhangXLiQXuJZhouXWangTPromoter hypomethylation of TIMP3 is associated with pre-eclampsia in a Chinese populationMol Hum Reprod20131915391:CAS:528:DC%2BC3sXjtF2kt78%3D10.1093/molehr/gas05423172037
– reference: YuanYWangJLiJWangLLiMYangZFrequent epigenetic inactivation of spleen tyrosine kinase gene in human hepatocellular carcinomaClin Cancer Res20061266879518321521:CAS:528:DC%2BD28Xht1elsL%2FI10.1158/1078-0432.CCR-06-092117121887
– reference: LeiHHemminkiKAltieriAJohanssonREnquistKHallmansGPromoter polymorphisms in matrix metalloproteinases and their inhibitors: few associations with breast cancer susceptibility and progressionBreast Cancer Res Treat20071036191:CAS:528:DC%2BD2sXksFans7w%3D10.1007/s10549-006-9345-217033924
– reference: HaoKLukJMLeeNPMaoMZhangCFergusonMDPredicting prognosis in hepatocellular carcinoma after curative surgery with common clinicopathologic parametersBMC Cancer20099389278583510.1186/1471-2407-9-38919886989
– reference: SeongJChallenge and hope in radiotherapy of hepatocellular carcinomaYonsei Med J20095060112276823210.3349/ymj.2009.50.5.60119881961
– reference: HeYCuiYWangWGuJGuoSMaKHypomethylation of the hsa-mir-191 locus causes high expression of hsa-mir-191 and promotes the epithelial-to-mesenchymal transition in hepatocellular carcinomaNeoplasia2011138415331822761:CAS:528:DC%2BC3MXhsF2isbvJ10.1593/neo.1169821969817
– reference: BanJYYoonKLKimSKKangSChungJHPromoter polymorphism (rs3755724, −55c/t) of tissue inhibitor of metalloproteinase 4 (TIMP4) as a risk factor for Kawasaki disease with coronary artery lesions in a Korean populationPediatr Cardiol200930331510.1007/s00246-008-9341-x19048177
– reference: WuCSYenCJChouRHLiSTHuangWCRenCTCancer-associated carbohydrate antigens as potential biomarkers for hepatocellular carcinomaPLoS ONE20127e3946633966211:CAS:528:DC%2BC38XhtVyisrjE10.1371/journal.pone.003946622808038
– reference: ChenYLTsengHSKuoWHYangSFChenDRTsaiHTGlutathione s-transferase p1 (GSTP1) gene polymorphism increases age-related susceptibility to hepatocellular carcinomaBMC Med Genet20101146285159310.1186/1471-2350-11-4620331903
– reference: YehCBTsaiHTChenYCKuoWHChenTYHsiehYHGenetic polymorphism of CCR2-64I increased the susceptibility of hepatocellular carcinomaJ Surg Oncol2010102264701:CAS:528:DC%2BC3cXhtFOhsrvM10.1002/jso.2162320740585
– reference: WieczorekEReszkaEJablonowskiZJablonskaEBeata KrolMGrzegorczykAGenetic polymorphisms in matrix metalloproteinases (MMPs) and tissue inhibitors of MPs (TIMPs), and bladder cancer susceptibilityBJU Int20131121207141:CAS:528:DC%2BC3sXhslCgur%2FO10.1111/bju.1223023819551
– reference: YuYLWeiCWChenYLChenMHYiangGTImmunotherapy of breast cancer by single delivery with raav2-mediated interleukin-15 expressionInt J Oncol201036365701:CAS:528:DC%2BC3cXitF2gtrg%3D10.3892/ijo_0000060320043070
– reference: OkitaKManagement of hepatocellular carcinoma in JapanJ Gastroenterol200641100610.1007/s00535-005-1763-016568368
– reference: El HajjECEl HajjMCVoloshenyukTGMoutonAJKhoutorovaEMolinaPEAlcohol modulation of cardiac matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs favors collagen accumulationAlcohol Clin Exp Res20143844856408081210.1111/acer.1223924033327
– reference: OgataTShibamuraHTrompGSinhaMGoddardKASakalihasanNGenetic analysis of polymorphisms in biologically relevant candidate genes in patients with abdominal aortic aneurysmsJ Vasc Surg200541103642124949910.1016/j.jvs.2005.02.02015944607
– reference: YiangGTHarnHJYuYLHuSCHungYTHsiehCJImmunotherapy: rAAV2 expressing interleukin-15 inhibits Hela cell tumor growth in miceJ Biomed Sci20091647268743210.1186/1423-0127-16-4719422685
– reference: WangBHsuSHMajumderSKutayHHuangWJacobSTTGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3Oncogene20102917879728457431:CAS:528:DC%2BD1MXhsFyhsLvO10.1038/onc.2009.46820023698
– reference: PilkaRDomanskiHHanssonSErikssonPCasslenBEndometrial TIMP-4 mRNA is high at midcycle and in hyperplasia, but down-regulated in malignant tumours. Coordinated expression with mmp-26Mol Hum Reprod200410641501:CAS:528:DC%2BD2cXntFamsLg%3D10.1093/molehr/gah09215273280
– reference: RiddickACShuklaCJPenningtonCJBassRNuttallRKHoganAIdentification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissuesBr J Cancer20059221718023618191:CAS:528:DC%2BD2MXltVygtLs%3D10.1038/sj.bjc.660263015928670
– reference: DammannRStrunnikovaMSchagdarsurenginURastetterMPapritzMHattenhorstUECpG island methylation and expression of tumour-associated genes in lung carcinomaEur J Cancer2005411223361:CAS:528:DC%2BD2MXks1Gjt74%3D10.1016/j.ejca.2005.02.02015911247
– reference: HassanZKDaghestaniMHCurcumin effect on MMPs and TIMPs genes in a breast cancer cell lineAsian Pac J Cancer Prev20121332596410.7314/APJCP.2012.13.7.325922994744
– reference: PetersonNBBeeghly-FadielAGaoYTLongJCaiQShuXOPolymorphisms in tissue inhibitors of metalloproteinases-2 and −3 and breast cancer susceptibility and survivalInt J Cancer20091258445027459951:CAS:528:DC%2BD1MXnsFeltL4%3D10.1002/ijc.2440519431211
– reference: PilkaRObornaILichnovskyVHavelkaPFingerovaHErikssonPEndometrial expression of the estrogen-sensitive genes MMP-26 and TIMP-4 is altered by a substitution protocol without down-regulation in IVF patientsHum Reprod2006213146561:CAS:528:DC%2BD28XhtlChtLfJ10.1093/humrep/del18017012332
– reference: WildARamaswamyALangerPCelikIFendrichVChaloupkaBFrequent methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene in pancreatic endocrine tumorsJ Clin Endocrinol Metab2003881367731:CAS:528:DC%2BD3sXit1ensb4%3D10.1210/jc.2002-02102712629131
– reference: HishidaMNomotoSInokawaYHayashiMKandaMOkamuraYEstrogen receptor 1 gene as a tumor suppressor gene in hepatocellular carcinoma detected by triple-combination array analysisInt J Oncol20134388941:CAS:528:DC%2BC3sXhtFOltLrM23695389
– reference: NakamuraMIshidaEShimadaKKishiMNakaseHSakakiTFrequent LOH on 22q12.3 and TIMP-3 inactivation occur in the progression to secondary glioblastomasLab Investig200585165751:CAS:528:DC%2BD2MXhtFWgtLo%3D10.1038/labinvest.370022315592495
– reference: YuMWChangHCChangSCLiawYFLinSMLiuCJRole of reproductive factors in hepatocellular carcinoma: impact on hepatitis b- and c-related riskHepatology200338139340014647050
– reference: LiuWHYehSHLuCCYuSLChenHYLinCYMicrorna-18a prevents estrogen receptor-alpha expression, promoting proliferation of hepatocellular carcinoma cellsGastroenterology2009136683931:CAS:528:DC%2BD1MXislOhtbY%3D10.1053/j.gastro.2008.10.02919027010
– reference: MenghiniRMeniniSAmorusoRFiorentinoLCasagrandeVMarzanoVTissue inhibitor of metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in miceGastroenterology2009136663721:CAS:528:DC%2BD1MXislOhtbg%3D10.1053/j.gastro.2008.10.07919027012e4
– reference: WangMLiuYEGreeneJShengSFuchsARosenEMInhibition of tumor growth and metastasis of human breast cancer cells transfected with tissue inhibitor of metalloproteinase 4Oncogene1997142767741:CAS:528:DyaK2sXktF2nt7c%3D10.1038/sj.onc.12012459190892
– reference: Centers for Disease Control, Taiwan http://www.cdc.gov.tw 2007
– reference: Department of Health: Republic of china: “Health promotion administration, ministry of health and welfare” department of health. Taipei 2013
– reference: Celebiler CavusogluAKilicYSaydamSCandaTBaskanZSevincAIPredicting invasive phenotype with CDH1, CDH13, CD44, and TIMP3 gene expression in primary breast cancerCancer Sci20091002341510.1111/j.1349-7006.2009.01333.x19799609
– reference: ShenBChuESZhaoGManKWuCWChengJTPPARgamma inhibits hepatocellular carcinoma metastases in vitro and in miceBr J Cancer201210614869433418691:CAS:528:DC%2BC38Xmt1Ghu74%3D10.1038/bjc.2012.13022472882
– reference: BruixJTreatment of hepatocellular carcinomaHepatology199725259621:STN:280:DyaK2s7nsVWqtQ%3D%3D10.1002/hep.5102502019021931
– reference: TranPLVigneronJPPericatDDuboisSCazalsDHervyMGene therapy for hepatocellular carcinoma using non-viral vectors composed of bis guanidinium-tren-cholesterol and plasmids encoding the tissue inhibitors of metalloproteinases TIMP-2 and TIMP-3Cancer Gene Ther200310435441:CAS:528:DC%2BD3sXjvF2lu7w%3D10.1038/sj.cgt.770059212768188
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Snippet The purpose of this study was to investigate genetic impact of TIMP-3 -1296 T>C (rs9619311) and TIMP-4 -55 T>C (rs3755724) gene polymorphisms on the...
The purpose of this study was to investigate genetic impact of TIMP-3 -1296 T>C (rs9619311) and TIMP-4 -55 T>C (rs3755724) gene polymorphisms on the...
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SubjectTerms Analysis of Variance
Asian People - genetics
Biomarkers
Biomedical and Life Sciences
Biomedicine
Cancer Research
Carcinoma, Hepatocellular - ethnology
Carcinoma, Hepatocellular - genetics
Case-Control Studies
Cellular biology
Female
Gene Frequency
Genetic Predisposition to Disease - ethnology
Genetic Predisposition to Disease - genetics
Genetics
Genotype
Hepatology
Humans
Linkage Disequilibrium
Liver Neoplasms - ethnology
Liver Neoplasms - genetics
Male
Middle Aged
Polymorphism
Polymorphism, Single Nucleotide
Research Article
Risk Factors
Sex Factors
Taiwan
Tissue Inhibitor of Metalloproteinase-3 - genetics
Tissue Inhibitor of Metalloproteinase-4
Tissue Inhibitor of Metalloproteinases - genetics
Womens health
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Title TIMP-3 -1296 T>C and TIMP-4 -55 T>C gene polymorphisms play a role in the susceptibility of hepatocellular carcinoma among women
URI https://link.springer.com/article/10.1007/s13277-014-2170-z
https://www.ncbi.nlm.nih.gov/pubmed/24903383
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Volume 35
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