Adolescent brain development and depression: A case for the importance of connectivity of the anterior cingulate cortex

• Published in: Neuroscience and biobehavioral reviews Vol. 70; pp. 271 - 287
• Main Authors: Lichenstein, Sarah D., Verstynen, Timothy, Forbes, Erika E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.11.2016
• Subjects: Adolescence; Adolescent; Affect regulation; Anterior cingulate cortex; Connectivity; Depression; Development; Gyrus Cinguli; Humans; Magnetic Resonance Imaging; Neural Pathways; Prospective Studies; ACC; Adolescence; AD; SUD; Anterior cingulate cortex; Depression; RSN; ROI; RD; rsfMRI; MD; DTI; Development; Connectivity; Affect regulation; FA; ATR

•Anterior cingulate cortex (ACC) is key to adolescent developmental psychopathology.•A meta-analysis shows linear adolescent development of ACC-relevant tracts.•ACC functional connectivity increases to default mode and salience networks.•ACC connectivity is disrupted in adolescent depression. We pro...