Associations between TCF4 Gene Polymorphism and Cognitive Functions in Schizophrenia Patients and Healthy Controls

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 38; no. 4; pp. 683 - 689
• Main Authors: Zhu, Xianghua, Gu, Huang, Liu, Zhen, Xu, Zhansheng, Chen, Xiongying, Sun, Xiaochen, Zhai, Jinguo, Zhang, Qiumei, Chen, Min, Wang, Keqin, Deng, Xiaoxiang, Ji, Feng, Liu, Chuanxin, Li, Jun, Dong, Qi, Chen, Chuansheng
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.03.2013
• Subjects: Adolescent; Adult; Adult and adolescent clinical studies; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics; Biological and medical sciences; Cognition - physiology; Female; Genetic Association Studies - methods; Head injuries; Humans; Male; Medical sciences; Memory; Original; Patients; Polymorphism; Polymorphism, Genetic - genetics; Psychiatrists; Psychologists; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Schizophrenia; Schizophrenia - genetics; Schizophrenic Psychology; Transcription Factor 4; Transcription Factors - genetics; Young Adult; Beijing China; China; Psychosis; Human; Gene; Healthy subject; Attention; Schizophrenia; Genetics; Cognition; TCF4; Working memory; Polymorphism

The SNP rs2958182 was reported to be significantly associated with schizophrenia (SCZ) in Han Chinese. This study examined this SNP's associations with cognitive functions in 580 SCZ patients and 498 controls. Cognitive functions were assessed using the Wechsler Adult Intelligence Scale-Revised...