Do not judge a cell by its cover—diversity of CNS resident, adjoining and infiltrating myeloid cells in inflammation

• Published in: Seminars in Immunopathology Vol. 37; no. 6; pp. 591 - 605
• Main Authors: Brendecke, Stefanie M., Prinz, Marco
• Format: Journal Article Book Review
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2015; Springer Nature B.V
• Subjects: Animals; Antigen-Presenting Cells - immunology; Biomedical and Life Sciences; Biomedicine; Central Nervous System - cytology; Central Nervous System - immunology; Central Nervous System - pathology; Encephalomyelitis, Autoimmune, Experimental - immunology; Encephalomyelitis, Autoimmune, Experimental - pathology; Humans; Immunology; Internal Medicine; Mice; Microglia - cytology; Microglia - immunology; Multiple Sclerosis - immunology; Multiple Sclerosis - pathology; Myeloid Cells - cytology; Myeloid Cells - immunology; Review; EAE; Neuroinflammation; Meninges; Myeloid cell; MS; Microglia

Specialized populations of tissue-resident myeloid cells inhabit every organ of the body. While many of these populations appear similar morphologically and phenotypically, they exhibit great functional diversity. The central nervous system (CNS), as an immune privileged organ, possesses a unique ti...