Effects of Exercise on DNA Methylation: A Systematic Review of Randomized Controlled Trials

• Published in: Sports medicine (Auckland) Vol. 54; no. 8; pp. 2059 - 2069
• Main Authors: Etayo-Urtasun, Paula, Sáez de Asteasu, Mikel L., Izquierdo, Mikel
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.08.2024; Springer Nature B.V
• Subjects: Alzheimer's disease; Cancer; Clinical trials; Diabetes; Disease prevention; DNA Methylation; Dose-response effects; Epigenetics; Exercise; Exercise - physiology; Gene expression; Humans; Intervention; Life span; Measurement techniques; Medicine; Medicine & Public Health; Molecular modelling; Nucleotide sequence; Physical fitness; Population studies; Randomized Controlled Trials as Topic; Sports Medicine; Systematic Review

Background Regular exercise reduces chronic disease risk and extends a healthy lifespan, but the underlying molecular mechanisms remain unclear. DNA methylation is implicated in this process, potentially altering gene expression without changing DNA sequence. However, previous findings appear partly...