PET imaging of [11C]PBR28 in Parkinson’s disease patients does not indicate increased binding to TSPO despite reduced dopamine transporter binding

• Published in: European journal of nuclear medicine and molecular imaging Vol. 46; no. 2; pp. 367 - 375
• Main Authors: Varnäs, Katarina, Cselényi, Zsolt, Jucaite, Aurelija, Halldin, Christer, Svenningsson, Per, Farde, Lars, Varrone, Andrea
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2019; Springer Nature B.V
• Subjects: Affinity; Binding; Brain; Cardiology; Diagnostic systems; Dopamine; Dopamine receptors; Dopamine transporter; Fluorine isotopes; Gene polymorphism; Hypotheses; Imaging; Medical imaging; Medicine; Medicine & Public Health; Microglia; Movement disorders; Neurodegenerative diseases; Neuroimaging; Nuclear Medicine; Oncology; Original; Original Article; Orthopedics; Parkinson's disease; Pathology; Patients; Polymorphism; Positron emission; Positron emission tomography; Proteins; Radiology; Statistical analysis; Thalamus; Tomography; Dopamine transporter; PET imaging; 18 kDa translocator protein; Parkinson’s disease

Purpose To examine the hypothesis that cerebral binding to the 18 kDa translocator protein (TSPO), a marker of microglia activation, is elevated in Parkinson’s disease (PD), and to assess the relationship between brain TSPO binding and dopaminergic pathology in PD. Methods The radioligand [ 11 C]PBR...