Mortality among Japanese with a history of Kawasaki disease: results at the end of 2009

The long-term outcomes of Kawasaki disease (KD) are unknown. Fifty-two collaborating hospitals collected data on all patients who had received a new definite diagnosis of KD between July 1982 and December 1992. Patients were followed until December 31, 2009 or death. Standardized mortality ratios (S...

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Published inJournal of epidemiology Vol. 23; no. 6; pp. 429 - 434
Main Authors Nakamura, Yosikazu, Aso, Eiko, Yashiro, Mayumi, Tsuboi, Satoshi, Kojo, Takao, Aoyama, Yasuko, Kotani, Kazuhiko, Uehara, Ritei, Yanagawa, Hiroshi
Format Journal Article
LanguageEnglish
Published Japan Japan Epidemiological Association 01.11.2013
Subjects
Adolescent
Adult
Cardiovascular Disease
Epidemiology
Female
Follow-Up Studies
Heart Diseases - etiology
Humans
Japan - epidemiology
Male
Mortality
Mucocutaneous Lymph Node Syndrome - complications
Mucocutaneous Lymph Node Syndrome - mortality
Original
Survival Rate
Vein & artery diseases
Young Adult
Japan
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Abstract The long-term outcomes of Kawasaki disease (KD) are unknown. Fifty-two collaborating hospitals collected data on all patients who had received a new definite diagnosis of KD between July 1982 and December 1992. Patients were followed until December 31, 2009 or death. Standardized mortality ratios (SMRs) were calculated based on Japanese vital statistics data. Of the 6576 patients enrolled, 46 (35 males and 11 females) died (SMR: 1.00; 95% CI: 0.73-1.34). Among persons without cardiac sequelae, SMRs were not high after the acute phase of KD (SMR: 0.65; 95% CI: 0.41-0.96). Among persons with cardiac sequelae, 13 males and 1 female died during the observation period (SMR: 1.86; 95% CI: 1.02-3.13). In this cohort, the mortality rate among Japanese with cardiac sequelae due to KD was significantly higher than that of the general population. In contrast, the rates for males and females without sequelae were not elevated.
AbstractList Background: The long-term outcomes of Kawasaki disease (KD) are unknown. Methods: Fifty-two collaborating hospitals collected data on all patients who had received a new definite diagnosis of KD between July 1982 and December 1992. Patients were followed until December 31, 2009 or death. Standardized mortality ratios (SMRs) were calculated based on Japanese vital statistics data. Results: Of the 6576 patients enrolled, 46 (35 males and 11 females) died (SMR: 1.00; 95% CI: 0.73-1.34). Among persons without cardiac sequelae, SMRs were not high after the acute phase of KD (SMR: 0.65; 95% CI: 0.41-0.96). Among persons with cardiac sequelae, 13 males and 1 female died during the observation period (SMR: 1.86; 95% CI: 1.02-3.13). Conclusions: In this cohort, the mortality rate among Japanese with cardiac sequelae due to KD was significantly higher than that of the general population. In contrast, the rates for males and females without sequelae were not elevated.[PUBLICATION ABSTRACT]
The long-term outcomes of Kawasaki disease (KD) are unknown. Fifty-two collaborating hospitals collected data on all patients who had received a new definite diagnosis of KD between July 1982 and December 1992. Patients were followed until December 31, 2009 or death. Standardized mortality ratios (SMRs) were calculated based on Japanese vital statistics data. Of the 6576 patients enrolled, 46 (35 males and 11 females) died (SMR: 1.00; 95% CI: 0.73-1.34). Among persons without cardiac sequelae, SMRs were not high after the acute phase of KD (SMR: 0.65; 95% CI: 0.41-0.96). Among persons with cardiac sequelae, 13 males and 1 female died during the observation period (SMR: 1.86; 95% CI: 1.02-3.13). In this cohort, the mortality rate among Japanese with cardiac sequelae due to KD was significantly higher than that of the general population. In contrast, the rates for males and females without sequelae were not elevated.
Author Kojo, Takao
Uehara, Ritei
Aoyama, Yasuko
Tsuboi, Satoshi
Yanagawa, Hiroshi
Aso, Eiko
Nakamura, Yosikazu
Yashiro, Mayumi
Kotani, Kazuhiko
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2013 Yosikazu Nakamura et al. 2013 Yosikazu Nakamura et al
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Snippet The long-term outcomes of Kawasaki disease (KD) are unknown. Fifty-two collaborating hospitals collected data on all patients who had received a new definite...
Background: The long-term outcomes of Kawasaki disease (KD) are unknown. Methods: Fifty-two collaborating hospitals collected data on all patients who had...
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SubjectTerms Adolescent
Adult
Cardiovascular Disease
Epidemiology
Female
Follow-Up Studies
Heart Diseases - etiology
Humans
Japan - epidemiology
Male
Mortality
Mucocutaneous Lymph Node Syndrome - complications
Mucocutaneous Lymph Node Syndrome - mortality
Original
Survival Rate
Vein & artery diseases
Young Adult
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Title Mortality among Japanese with a history of Kawasaki disease: results at the end of 2009
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