Exploring the mechanisms underlying the therapeutic effect of Salvia miltiorrhiza in diabetic nephropathy using network pharmacology and molecular docking

• Published in: Bioscience reports Vol. 41; no. 6
• Main Authors: Zhang, Lili, Han, Lin, Wang, Xinmiao, Wei, Yu, Zheng, Jinghui, Zhao, Linhua, Tong, Xiaolin
• Format: Journal Article
• Language: English
• Published: England Portland Press Ltd The Biochemical Society 25.06.2021; Portland Press Ltd
• Subjects: Acids; Advanced glycosylation end products; AKT protein; AKT1 protein; Animals; Bioinformatics; Databases, Genetic; Diabetes; Diabetes & Metabolic Disorders; Diabetes mellitus; Diabetic Nephropathies - drug therapy; Diabetic Nephropathies - genetics; Diabetic Nephropathies - metabolism; Diabetic nephropathy; Drugs, Chinese Herbal - isolation & purification; Drugs, Chinese Herbal - pharmacology; Encyclopedias; Endocrinology; Epidermal growth factor receptors; Function analysis; Gene Expression Regulation; Gene mapping; Gene Regulatory Networks; Genes; Genomes; Growth factors; Herbal medicine; Humans; Immunoregulation; Inflammation; Inflammatory response; Ingredients; Interleukin 6; Kidney diseases; Kinases; Ligands; MAP kinase; Metabolism; Molecular docking; Molecular Docking Simulation; Nephropathy; Network Pharmacology; Oxidative stress; p53 Protein; Pharmacology; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Protein Interaction Maps; Protein-serine/threonine kinase; Proteins; Salvia miltiorrhiza; Salvia miltiorrhiza - chemistry; Signal Transduction; Software; Stat3 protein; Systems Biology & Networks; Traditional Chinese medicine; Tumor necrosis factor; Salvia miltiorrhiza; molecular mechanism; molecular docking; network pharmacology; diabetic nephropathy

The mechanisms underlying the therapeutic effect of Salvia miltiorrhiza (SM) on diabetic nephropathy (DN) were examined using a systematic network pharmacology approach and molecular docking. The Traditional Chinese Medicine Systems Pharmacology (TCMSP) database was used to screen active ingredients...