Neuropeptide signalling orchestrates T cell differentiation

• Published in: Nature (London) Vol. 635; no. 8038; pp. 444 - 452
• Main Authors: Hou, Yu, Sun, Linyu, LaFleur, Martin W., Huang, Linglin, Lambden, Conner, Thakore, Pratiksha I., Geiger-Schuller, Kathryn, Kimura, Kimitoshi, Yan, Longjun, Zang, Yue, Tang, Ruihan, Shi, Jingwen, Barilla, Rocky, Deng, Liwen, Subramanian, Ayshwarya, Wallrapp, Antonia, Choi, Hee Sun, Kye, Yoon-Chul, Ashenberg, Orr, Schiebinger, Geoffrey, Doench, John G., Chiu, Isaac M., Regev, Aviv, Sharpe, Arlene H., Kuchroo, Vijay K.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.11.2024; Nature Publishing Group
• Subjects: 631/250/2152; 631/250/2502; 64/60; 96; 96/21; Activating transcription factor 3; Activating Transcription Factor 3 - metabolism; Animals; Antiviral agents; Antiviral drugs; Calcitonin; Calcitonin gene-related peptide; Calcitonin Gene-Related Peptide - metabolism; Calcitonin Receptor-Like Protein - metabolism; CD8 antigen; Cell activation; Cell culture; Cell cycle; Cell Differentiation; Cell fate; COVID-19; CRISPR; Cyclic AMP response element-binding protein; Cyclic AMP Response Element-Binding Protein - metabolism; Cytokines; Differentiation (biology); Female; Helper cells; Humanities and Social Sciences; In vivo methods and tests; Infections; Lymphocytes; Lymphocytes T; Male; Mice; Mice, Inbred C57BL; multidisciplinary; Neurons; Neuropeptides; Receptor activity modifying proteins; Receptor Activity-Modifying Protein 3 - metabolism; Receptors; Science; Science (multidisciplinary); Signal Transduction; Stat1 protein; STAT1 Transcription Factor - metabolism; Th1 Cells - cytology; Th1 Cells - immunology; Th1 Cells - metabolism; Th2 Cells - cytology; Th2 Cells - immunology; Th2 Cells - metabolism; Transcription activation; Transcription factors; Viral infections; γ-Interferon

The balance between T helper type 1 (T H 1) cells and other T H cells is critical for antiviral and anti-tumour responses 1 – 3 , but how this balance is achieved remains poorly understood. Here we dissected the dynamic regulation of T H 1 cell differentiation during in vitro polarization, and durin...