Bioactivation and detoxification of organophosphorus pesticides in freshwater planarians shares similarities with humans

• Published in: Archives of toxicology Vol. 96; no. 12; pp. 3233 - 3243
• Main Authors: Ireland, Danielle, Rabeler, Christina, Gong, TaiXi, Collins, Eva-Maria S.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2022; Springer Nature B.V
• Subjects: Acetylcholinesterase; Animals; Aryldialkylphosphatase; Benzil; Biocompatibility; Biological activity; Biomedical and Life Sciences; Biomedicine; Butyrylcholinesterase; Carboxylesterase; Carboxylic Ester Hydrolases; Chlorpyrifos; Chlorpyrifos - toxicity; Cholinesterase; Cholinesterase Inhibitors - toxicity; Cytochrome; Cytochrome P-450 Enzyme System - metabolism; Cytochrome P450; Cytochromes P450; Detoxification; Diazinon; Diazinon - toxicity; Environmental Health; Fresh Water; Fungicides; Humans; In vivo methods and tests; Insecticides; Insecticides - metabolism; Insecticides - toxicity; Metabolic activation; Metabolic rate; Metabolism; Neurotoxicity; Neurotoxicity Syndromes; Occupational Medicine/Industrial Medicine; Organophosphorus Compounds - metabolism; Organophosphorus Compounds - toxicity; Organophosphorus pesticides; Paraoxonase; Pesticides; Pesticides - metabolism; Pesticides - toxicity; Pharmacology/Toxicology; Planarians; Proteins; Tacrine; Toxicity; Toxikokinetics and Metabolism; Planarians; Organophosphorus pesticides; Paraoxonase; Metabolism; Carboxylesterase; Bioactivation

Organophosphorus pesticides (OPs) are a chemically diverse class of insecticides that inhibit acetylcholinesterase (AChE). Many OPs require bioactivation to their active oxon form via cytochrome P450 to effectively inhibit AChE. OP toxicity can be mitigated by detoxification reactions performed by c...