Effect of oleic acid on store-operated calcium entry in immune-competent cells

• Published in: European journal of nutrition Vol. 56; no. 3; pp. 1077 - 1084
• Main Authors: Carrillo, Celia, Giraldo, María, Cavia, M. Mar, Alonso-Torre, Sara R.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2017; Springer Nature B.V
• Subjects: Calcium - metabolism; Cell Line; Chemistry; Chemistry and Materials Science; Dose-Response Relationship, Drug; Econazole - pharmacology; Fura-2 - metabolism; Humans; Jurkat Cells; Manganese - metabolism; Nutrition; Oleic Acid - pharmacology; Original Contribution; Thapsigargin - pharmacology; SOCE; signals; Oleic acid; Ca; Immune-competent cells; Ca2+ signals

Purpose To study the mechanism by which oleic acid (OA) (C18:1) exerts its beneficial effects on immune-competent cells. Since store-operated Ca 2+ entry (SOCE) is a Ca 2+ influx pathway involved in the control of multiple physiological processes including cell proliferation, we studied the effect o...