New inhibitor targeting Acyl-CoA synthetase 4 reduces breast and prostate tumor growth, therapeutic resistance and steroidogenesis

• Published in: Cellular and molecular life sciences : CMLS Vol. 78; no. 6; pp. 2893 - 2910
• Main Authors: Castillo, Ana F., Orlando, Ulises D., Maloberti, Paula M., Prada, Jesica G., Dattilo, Melina A., Solano, Angela R., Bigi, María M., Ríos Medrano, Mayra A., Torres, María T., Indo, Sebastián, Caroca, Graciela, Contreras, Hector R., Marelli, Belkis E., Salinas, Facundo J., Salvetti, Natalia R., Ortega, Hugo H., Lorenzano Menna, Pablo, Szajnman, Sergio, Gomez, Daniel E., Rodríguez, Juan B., Podesta, Ernesto J.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.03.2021; Springer Nature B.V
• Subjects: Animal models; Animals; Arachidonic acid; Binding Sites; Biochemistry; Bioinformatics; Biomedical and Life Sciences; Biomedicine; Breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cancer; Cell Biology; Cell culture; Cell Line, Tumor; Cell Movement - drug effects; Cell proliferation; Cell Proliferation - drug effects; Coenzyme A Ligases - antagonists & inhibitors; Coenzyme A Ligases - metabolism; Drug resistance; Drug Resistance, Neoplasm; Enzyme Inhibitors - metabolism; Enzyme Inhibitors - pharmacology; Enzyme Inhibitors - therapeutic use; Fatty acids; Female; Gene expression; Homology; Humans; Life Sciences; Male; Mass spectroscopy; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Docking Simulation; NMR; Nuclear magnetic resonance; Original; Original Article; Prostate; Prostate - cytology; Prostate - metabolism; Prostate cancer; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; Signal transduction; Steroidogenesis; Steroids; Steroids - blood; Synthesis; Tumor cells; Tumors; Xenograft Model Antitumor Assays; Anti-hormone treatment resistance; Chemotherapy resistance; Triple negative breast cancer; Castration resistant prostate cancer

Acyl-CoA synthetase 4 (ACSL4) is an isoenzyme of the fatty acid ligase-coenzyme-A family taking part in arachidonic acid metabolism and steroidogenesis. ACSL4 is involved in the development of tumor aggressiveness in breast and prostate tumors through the regulation of various signal transduction pa...