New inhibitor targeting Acyl-CoA synthetase 4 reduces breast and prostate tumor growth, therapeutic resistance and steroidogenesis

Acyl-CoA synthetase 4 (ACSL4) is an isoenzyme of the fatty acid ligase-coenzyme-A family taking part in arachidonic acid metabolism and steroidogenesis. ACSL4 is involved in the development of tumor aggressiveness in breast and prostate tumors through the regulation of various signal transduction pa...

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Published inCellular and molecular life sciences : CMLS Vol. 78; no. 6; pp. 2893 - 2910
Main Authors Castillo, Ana F., Orlando, Ulises D., Maloberti, Paula M., Prada, Jesica G., Dattilo, Melina A., Solano, Angela R., Bigi, María M., Ríos Medrano, Mayra A., Torres, María T., Indo, Sebastián, Caroca, Graciela, Contreras, Hector R., Marelli, Belkis E., Salinas, Facundo J., Salvetti, Natalia R., Ortega, Hugo H., Lorenzano Menna, Pablo, Szajnman, Sergio, Gomez, Daniel E., Rodríguez, Juan B., Podesta, Ernesto J.
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.03.2021
Springer Nature B.V
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Abstract Acyl-CoA synthetase 4 (ACSL4) is an isoenzyme of the fatty acid ligase-coenzyme-A family taking part in arachidonic acid metabolism and steroidogenesis. ACSL4 is involved in the development of tumor aggressiveness in breast and prostate tumors through the regulation of various signal transduction pathways. Here, a bioinformatics analysis shows that the ACSL4 gene expression and proteomic signatures obtained using a cell model was also observed in tumor samples from breast and cancer patients. A well-validated ACSL4 inhibitor, however, has not been reported hindering the full exploration of this promising target and its therapeutic application on cancer and steroidogenesis inhibition. In this study, ACSL4 inhibitor PRGL493 was identified using a homology model for ACSL4 and docking based virtual screening. PRGL493 was then chemically characterized through nuclear magnetic resonance and mass spectroscopy. The inhibitory activity was demonstrated through the inhibition of arachidonic acid transformation into arachidonoyl-CoA using the recombinant enzyme and cellular models. The compound blocked cell proliferation and tumor growth in both breast and prostate cellular and animal models and sensitized tumor cells to chemotherapeutic and hormonal treatment. Moreover, PGRL493 inhibited de novo steroid synthesis in testis and adrenal cells, in a mouse model and in prostate tumor cells. This work provides proof of concept for the potential application of PGRL493 in clinical practice. Also, these findings may prove key to therapies aiming at the control of tumor growth and drug resistance in tumors which express ACSL4 and depend on steroid synthesis.
AbstractList Acyl-CoA synthetase 4 (ACSL4) is an isoenzyme of the fatty acid ligase-coenzyme-A family taking part in arachidonic acid metabolism and steroidogenesis. ACSL4 is involved in the development of tumor aggressiveness in breast and prostate tumors through the regulation of various signal transduction pathways. Here, a bioinformatics analysis shows that the ACSL4 gene expression and proteomic signatures obtained using a cell model was also observed in tumor samples from breast and cancer patients. A well-validated ACSL4 inhibitor, however, has not been reported hindering the full exploration of this promising target and its therapeutic application on cancer and steroidogenesis inhibition. In this study, ACSL4 inhibitor PRGL493 was identified using a homology model for ACSL4 and docking based virtual screening. PRGL493 was then chemically characterized through nuclear magnetic resonance and mass spectroscopy. The inhibitory activity was demonstrated through the inhibition of arachidonic acid transformation into arachidonoyl-CoA using the recombinant enzyme and cellular models. The compound blocked cell proliferation and tumor growth in both breast and prostate cellular and animal models and sensitized tumor cells to chemotherapeutic and hormonal treatment. Moreover, PGRL493 inhibited de novo steroid synthesis in testis and adrenal cells, in a mouse model and in prostate tumor cells. This work provides proof of concept for the potential application of PGRL493 in clinical practice. Also, these findings may prove key to therapies aiming at the control of tumor growth and drug resistance in tumors which express ACSL4 and depend on steroid synthesis.
Author Marelli, Belkis E.
Gomez, Daniel E.
Contreras, Hector R.
Szajnman, Sergio
Salinas, Facundo J.
Podesta, Ernesto J.
Maloberti, Paula M.
Lorenzano Menna, Pablo
Indo, Sebastián
Solano, Angela R.
Salvetti, Natalia R.
Prada, Jesica G.
Torres, María T.
Rodríguez, Juan B.
Orlando, Ulises D.
Dattilo, Melina A.
Ortega, Hugo H.
Bigi, María M.
Caroca, Graciela
Castillo, Ana F.
Ríos Medrano, Mayra A.
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  email: ernestopodesta@yahoo.com.ar, inbiomed@fmed.uba.ar
  organization: Instituto de Investigaciones Biomédicas (INBIOMED), CONICET, Universidad de Buenos Aires, Departamento de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos Aires
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33068124$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1073/pnas.191367098
10.1016/0167-4889(95)00177-8
10.3892/or.2016.5094
10.1677/jme.1.01691
10.1038/bjc.2016.294
10.1074/jbc.M010793200
10.1158/0008-5472.CAN-18-2529
10.1158/1078-0432.CCR-18-3399
10.1371/journal.pone.0040794
10.4172/2329-8936.1000120
10.1073/pnas.94.7.2880
10.1016/S0021-9258(18)46930-X
10.1038/35021093
10.1194/jlr.E400002-JLR200
10.1194/jlr.M072512
10.1111/j.1349-7006.2003.tb01458.x
10.1073/pnas.80.3.702
10.1146/annurev.physiol.63.1.193
10.3892/or.2015.3746
10.1194/jlr.M015552
10.1007/s10863-017-9725-9
10.1016/j.mce.2008.08.013
10.1016/j.ccell.2020.01.010
10.1038/nrc4016
10.1016/j.lungcan.2013.09.019
10.1002/ijc.23013
10.1016/S0021-9258(18)50457-9
10.1016/J.BCP.2018.11.005
10.1002/jbt.20009
10.1016/S0021-9258(19)70116-1
10.3389/fonc.2018.00031
10.1111/j.1742-4658.2006.05496.x
10.3322/caac.21492
10.3389/fendo.2016.00060
10.1021/bi00900a036
10.1016/j.bbamem.2014.06.017
10.1007/s12672-017-0299-0
10.1056/NEJMra1701695
10.1074/jbc.M400100200
10.1093/annonc/mdy072
10.1210/er.2010-0013
10.1530/REP-08-0491
10.1016/S0014-5793(00)01376-4
10.1593/tlo.09202
10.3390/ijms20153624
10.1007/s12672-016-0259-0
10.1016/j.bbalip.2007.02.012
10.1016/j.cellsig.2019.109422
10.1111/j.1742-4658.2005.04616.x
10.1016/j.jsbmb.2014.09.004
10.1371/journal.pone.0077060
10.3748/wjg.v21.i12.3492
10.1371/journal.pone.0015540
10.1073/pnas.76.4.1896
10.1016/j.cell.2015.09.033
10.1093/jn/132.8.2123
10.1194/jlr.M600150-JLR200
10.1016/j.bbalip.2009.09.024
10.1016/j.lfs.2011.10.004
10.2174/1389201043376616
10.2337/db06-0267
10.1158/0008-5472.CAN-13-2699
10.1046/j.1432-1033.2002.03267.x
10.18632/oncotarget.5340
10.18632/oncotarget.6438
10.18632/oncotarget.5822
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Springer Nature Switzerland AG 2020.
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Thu Dec 05 23:43:50 EST 2024
Tue Nov 19 06:03:11 EST 2024
Fri Dec 06 05:16:35 EST 2024
Sat Nov 02 12:30:20 EDT 2024
Sat Dec 16 12:10:09 EST 2023
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Issue 6
Keywords Anti-hormone treatment resistance
Chemotherapy resistance
Triple negative breast cancer
Castration resistant prostate cancer
Language English
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References Gordon, Noble, Midha (CR55) 2019; 79
Hisanaga, Ago, Nakagawa (CR39) 2004; 279
Yamaguchi, Lucena-Araujo, Nakayama (CR23) 2014; 83
Sydes, Spears, Mason (CR59) 2018; 29
Watson, Arora, Sawyers (CR69) 2015; 15
Kang, Fujino, Sasano (CR43) 1997; 94
Monaco, Creighton, Lee (CR11) 2010; 3
Li, Klett, Coleman (CR45) 2010; 1801
Orlando, Garona, Ripoll (CR10) 2012; 7
Colombero, Papademetrio, Sacca (CR25) 2017; 8
Clark, Wells, King, Stocco (CR56) 1994; 269
Ko, Balk (CR66) 2005; 5
Castillo, Cornejo Maciel, Castilla (CR29) 2006; 273
Ortega, Salvetti, Padmanabhan (CR36) 2009; 135
Ciriello, Gatza, Beck (CR37) 2015; 163
Ascoli (CR26) 1981; 256
Cooke, Orlando, Maloberti (CR47) 2011; 52
Perou, Sørile, Eisen (CR2) 2000; 406
Mashek, Bornfeldt, Coleman (CR5) 2004; 45
Stocco (CR57) 2001; 63
Wu, Li, Wang (CR13) 2013; 8
Sudhan, Guerrero-Zotano, Won (CR24) 2020; 37
Chasalow, Marr, Haour, Saez (CR30) 1979; 256
Sorlie, Sørlie, Perou (CR3) 2001; 98
Long, Xu, Osunkoya (CR38) 2014; 74
Jiang, Guo, Zhang (CR58) 2020; 65
CR7
Sung, Hwang, Park (CR8) 2003; 94
Dechandt, Zuccolotto-dos-Reis, Teodoro (CR51) 2017; 49
Neophytou, Boutsikos, Papageorgis (CR60) 2018; 8
Privalle, Crivello, Jefcoate (CR20) 1983; 80
Maloberti, Lozano, Mele (CR50) 2002; 269
Paz, Cornejo Maciel, Gorostizaga (CR19) 2016; 7
Yamamoto, Kiguchi, Kobayashi (CR32) 2011; 89
Miller (CR63) 2007; 1771
Bray, Ferlay, Soerjomataram (CR1) 2018; 68
Mele, Dada, Paz (CR31) 1996; 1310
Dillard, Lin, Khan (CR65) 2008; 295
Maloberti, Duarte, Orlando (CR6) 2010; 5
Ripoll, Giron, Krzymuski (CR35) 2008; 25
Klett, Chen, Yechoor (CR46) 2017; 58
Miller, Auchus (CR64) 2011; 32
CR16
Armando, Gomez, Gomez (CR68) 2016; 36
Schönfeld, Wieckowski, Wojtczak (CR52) 2000; 471
CR12
Capper, Rae, Auchus (CR21) 2016; 7
Maloberti, Castilla, Castillo (CR18) 2005; 272
Yan, Yang, Liu (CR41) 2015; 12
Kim, Lewin, Coleman (CR28) 2001; 276
Sebastiano, Konstantinidou (CR61) 2019; 15
Sartor, de Bono, de Bono (CR4) 2018; 378
Askari, Kanter, Sherrid (CR40) 2007; 56
Pham, Deb, Ming (CR48) 2014; 144
Orlando, Castillo, Medrano (CR14) 2019; 159
Vessey, Kelley, Warren (CR49) 2004; 18
Orellana-Serradell, Poblete, Sanchez (CR33) 2015; 33
Hirshfield, Koritz (CR53) 1964; 3
Perera, Farina, Hernández (CR34) 2008; 122
Mashek, Li, Coleman (CR44) 2006; 47
Rae, Gutmann, Tsao, Schimmer (CR27) 2006; 76
Castillo, Orlando, Lopez (CR15) 2016; 3
Courtin, Smyth, Hearn (CR22) 2016; 115
Kazi, Xiang, Yang (CR67) 2019; 25
CR62
Cornejo Maciel, Maloberti, Neuman (CR17) 2005; 34
Belosludtsev, Belosludtseva, Agafonov (CR54) 2014; 1838
Coleman, Lewin, Van Horn, Gonzalez-Baró (CR42) 2002; 132
Cao, Dave, Doan, Prescott (CR9) 2001; 61
F Cornejo Maciel (3679_CR17) 2005; 34
P Maloberti (3679_CR50) 2002; 269
Y Cao (3679_CR9) 2001; 61
CP Capper (3679_CR21) 2016; 7
O Orellana-Serradell (3679_CR33) 2015; 33
A Courtin (3679_CR22) 2016; 115
Y Hisanaga (3679_CR39) 2004; 279
F Bray (3679_CR1) 2018; 68
DR Sudhan (3679_CR24) 2020; 37
A Yamamoto (3679_CR32) 2011; 89
GV Ripoll (3679_CR35) 2008; 25
JH Kim (3679_CR28) 2001; 276
PA Watson (3679_CR69) 2015; 15
T Sorlie (3679_CR3) 2001; 98
LO Li (3679_CR45) 2010; 1801
JA Gordon (3679_CR55) 2019; 79
C Colombero (3679_CR25) 2017; 8
X Jiang (3679_CR58) 2020; 65
F Chasalow (3679_CR30) 1979; 256
MJ Kang (3679_CR43) 1997; 94
EL Klett (3679_CR46) 2017; 58
PG Mele (3679_CR31) 1996; 1310
RA Coleman (3679_CR42) 2002; 132
HH Ortega (3679_CR36) 2009; 135
P Schönfeld (3679_CR52) 2000; 471
AF Castillo (3679_CR29) 2006; 273
B Askari (3679_CR40) 2007; 56
DG Mashek (3679_CR44) 2006; 47
PR Dillard (3679_CR65) 2008; 295
X Wu (3679_CR13) 2013; 8
S Yan (3679_CR41) 2015; 12
S Pham (3679_CR48) 2014; 144
C Neophytou (3679_CR60) 2018; 8
M Cooke (3679_CR47) 2011; 52
AF Castillo (3679_CR15) 2016; 3
N Yamaguchi (3679_CR23) 2014; 83
O Sartor (3679_CR4) 2018; 378
G Ciriello (3679_CR37) 2015; 163
Y Ko (3679_CR66) 2005; 5
M Ascoli (3679_CR26) 1981; 256
Q Long (3679_CR38) 2014; 74
DA Vessey (3679_CR49) 2004; 18
CRP Dechandt (3679_CR51) 2017; 49
BJ Clark (3679_CR56) 1994; 269
3679_CR62
DG Mashek (3679_CR5) 2004; 45
PA Rae (3679_CR27) 2006; 76
PM Maloberti (3679_CR6) 2010; 5
IN Hirshfield (3679_CR53) 1964; 3
UD Orlando (3679_CR10) 2012; 7
C Paz (3679_CR19) 2016; 7
UD Orlando (3679_CR14) 2019; 159
YK Sung (3679_CR8) 2003; 94
CT Privalle (3679_CR20) 1983; 80
WL Miller (3679_CR64) 2011; 32
A Kazi (3679_CR67) 2019; 25
CM Perou (3679_CR2) 2000; 406
MR Sydes (3679_CR59) 2018; 29
RG Armando (3679_CR68) 2016; 36
3679_CR7
3679_CR16
K Belosludtsev (3679_CR54) 2014; 1838
ME Monaco (3679_CR11) 2010; 3
Y Perera (3679_CR34) 2008; 122
3679_CR12
P Maloberti (3679_CR18) 2005; 272
WL Miller (3679_CR63) 2007; 1771
DM Stocco (3679_CR57) 2001; 63
MR Sebastiano (3679_CR61) 2019; 15
References_xml – volume: 98
  start-page: 10869
  year: 2001
  end-page: 10874
  ident: CR3
  article-title: Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.191367098
  contributor:
    fullname: Perou
– volume: 1310
  start-page: 260
  year: 1996
  end-page: 268
  ident: CR31
  article-title: Site of action of proteinases in the activation of steroidogenesis in rat adrenal gland
  publication-title: Biochim Biophys Acta
  doi: 10.1016/0167-4889(95)00177-8
  contributor:
    fullname: Paz
– volume: 36
  start-page: 2731
  year: 2016
  end-page: 2736
  ident: CR68
  article-title: AZT exerts its antitumoral effect by telomeric and non-telomeric effects in a mammary adenocarcinoma model
  publication-title: Oncol Rep
  doi: 10.3892/or.2016.5094
  contributor:
    fullname: Gomez
– volume: 34
  start-page: 655
  year: 2005
  end-page: 666
  ident: CR17
  article-title: An arachidonic acid-preferring acyl-CoA synthetase is a hormone-dependent and obligatory protein in the signal transduction pathway of steroidogenic hormones
  publication-title: J Mol Endocrinol
  doi: 10.1677/jme.1.01691
  contributor:
    fullname: Neuman
– volume: 115
  start-page: 1069
  year: 2016
  end-page: 1077
  ident: CR22
  article-title: Emergence of resistance to tyrosine kinase inhibitors in non-small-cell lung cancer can be delayed by an upfront combination with the HSP90 inhibitor onalespib
  publication-title: Br J Cancer
  doi: 10.1038/bjc.2016.294
  contributor:
    fullname: Hearn
– volume: 276
  start-page: 24667
  year: 2001
  end-page: 24673
  ident: CR28
  article-title: Expression and characterization of recombinant rat acyl-CoA synthetases 1, 4, and 5: selective inhibition by triacsin C and thiazolidinediones
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M010793200
  contributor:
    fullname: Coleman
– ident: CR16
– volume: 79
  start-page: 3320
  year: 2019
  end-page: 3331
  ident: CR55
  article-title: Upregulation of scavenger receptor B1 is required for steroidogenic and nonsteroidogenic cholesterol metabolism in prostate cancer
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-18-2529
  contributor:
    fullname: Midha
– volume: 25
  start-page: 5984
  year: 2019
  end-page: 5996
  ident: CR67
  article-title: Dual farnesyl and geranyl transferase inhibitor thwarts mutant KRAS-driven patient-derived pancreatic tumors
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-18-3399
  contributor:
    fullname: Yang
– volume: 7
  start-page: 1
  year: 2012
  end-page: 14
  ident: CR10
  article-title: The functional interaction between acyl-coa synthetase 4, 5-lipooxygenase and cyclooxygenase-2 controls tumor growth: a novel therapeutic target
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0040794
  contributor:
    fullname: Ripoll
– ident: CR12
– volume: 3
  start-page: 1
  year: 2016
  end-page: 9
  ident: CR15
  article-title: Gene expression profile and signaling pathways in MCF-7 breast cancer cells mediated by acyl-coa synthetase 4 overexpression
  publication-title: Transcr Open Access
  doi: 10.4172/2329-8936.1000120
  contributor:
    fullname: Lopez
– volume: 94
  start-page: 2880
  year: 1997
  end-page: 2884
  ident: CR43
  article-title: A novel arachidonate-preferring acyl-CoA synthetase is present in steroidogenic cells of the rat adrenal, ovary, and testis
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.94.7.2880
  contributor:
    fullname: Sasano
– volume: 269
  start-page: 28314
  year: 1994
  end-page: 28322
  ident: CR56
  article-title: The purification, cloning, and expression of a novel luteinizing hormone- induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR)
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(18)46930-X
  contributor:
    fullname: Stocco
– volume: 406
  start-page: 747
  year: 2000
  end-page: 752
  ident: CR2
  article-title: Molecular portraits of human breast tumours
  publication-title: Nature
  doi: 10.1038/35021093
  contributor:
    fullname: Eisen
– volume: 45
  start-page: 1958
  year: 2004
  end-page: 1961
  ident: CR5
  article-title: Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family
  publication-title: J Lipid Res
  doi: 10.1194/jlr.E400002-JLR200
  contributor:
    fullname: Coleman
– volume: 58
  start-page: 884
  year: 2017
  end-page: 894
  ident: CR46
  article-title: Long-chain acyl-CoA synthetase isoforms differ in preferences for eicosanoid species and long-chain fatty acids
  publication-title: J Lipid Res
  doi: 10.1194/jlr.M072512
  contributor:
    fullname: Yechoor
– volume: 94
  start-page: 421
  year: 2003
  end-page: 424
  ident: CR8
  article-title: Fatty acid-CoA ligase 4 is overexpressed in human hepatocellular carcinoma
  publication-title: Cancer Sci
  doi: 10.1111/j.1349-7006.2003.tb01458.x
  contributor:
    fullname: Park
– volume: 80
  start-page: 702
  year: 1983
  end-page: 706
  ident: CR20
  article-title: Regulation of intramitochondrial cholesterol transfer to side-chain cleavage cytochrome P-450 in rat adrenal gland
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.80.3.702
  contributor:
    fullname: Jefcoate
– volume: 63
  start-page: 193
  year: 2001
  end-page: 213
  ident: CR57
  article-title: StAR protein and the regulation of steroid hormone biosynthesis
  publication-title: Annu Rev Physiol
  doi: 10.1146/annurev.physiol.63.1.193
  contributor:
    fullname: Stocco
– volume: 33
  start-page: 1599
  year: 2015
  end-page: 1608
  ident: CR33
  article-title: Proapoptotic effect of endocannabinoids in prostate cancer cells
  publication-title: Oncol Rep
  doi: 10.3892/or.2015.3746
  contributor:
    fullname: Sanchez
– volume: 52
  start-page: 1936
  year: 2011
  end-page: 1948
  ident: CR47
  article-title: Tyrosine phosphatase SHP2 regulates the expression of acyl-CoA synthetase ACSL4
  publication-title: J Lipid Res
  doi: 10.1194/jlr.M015552
  contributor:
    fullname: Maloberti
– volume: 49
  start-page: 399
  year: 2017
  end-page: 411
  ident: CR51
  article-title: Triacsin C reduces lipid droplet formation and induces mitochondrial biogenesis in primary rat hepatocytes
  publication-title: J Bioenerg Biomembr
  doi: 10.1007/s10863-017-9725-9
  contributor:
    fullname: Teodoro
– volume: 295
  start-page: 115
  year: 2008
  end-page: 120
  ident: CR65
  article-title: Androgen-independent prostate cancer cells acquire the complete steroidogenic potential of synthesizing testosterone from cholesterol
  publication-title: Mol Cell Endocrinol
  doi: 10.1016/j.mce.2008.08.013
  contributor:
    fullname: Khan
– volume: 37
  start-page: 258
  issue: 2
  year: 2020
  end-page: 259
  ident: CR24
  article-title: Hyperactivation of Torc1 drives resistance to the pan-her tyrosine kinase inhibitor neratinib in Her2-mutant cancers
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2020.01.010
  contributor:
    fullname: Won
– volume: 25
  start-page: 2607
  year: 2008
  end-page: 2611
  ident: CR35
  article-title: Antitumor effects of desmopressin in combination with chemotherapeutic agents in a mouse model of breast cancer
  publication-title: Anticancer Res
  contributor:
    fullname: Krzymuski
– volume: 61
  start-page: 8429
  year: 2001
  end-page: 8434
  ident: CR9
  article-title: Fatty acid CoA ligase 4 is up-regulated in colon adenocarcinoma
  publication-title: Cancer Res
  contributor:
    fullname: Prescott
– volume: 15
  start-page: 701
  year: 2015
  end-page: 711
  ident: CR69
  article-title: Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc4016
  contributor:
    fullname: Sawyers
– volume: 83
  start-page: 37
  year: 2014
  end-page: 43
  ident: CR23
  article-title: Dual ALK and EGFR inhibition targets a mechanism of acquired resistance to the tyrosine kinase inhibitor crizotinib in ALK rearranged lung cancer
  publication-title: Lung Cancer
  doi: 10.1016/j.lungcan.2013.09.019
  contributor:
    fullname: Nakayama
– volume: 122
  start-page: 57
  year: 2008
  end-page: 62
  ident: CR34
  article-title: Systemic administration of a peptide that impairs the Protein Kinase (CK2) phosphorylation reduces solid tumor growth in mice
  publication-title: Int J Cancer
  doi: 10.1002/ijc.23013
  contributor:
    fullname: Hernández
– volume: 256
  start-page: 5613
  year: 1979
  end-page: 5617
  ident: CR30
  article-title: Testicular steroidogenesis after human chorionic gonadotropin desensitization in rats
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(18)50457-9
  contributor:
    fullname: Saez
– volume: 159
  start-page: 52
  year: 2019
  end-page: 63
  ident: CR14
  article-title: Acyl-CoA synthetase-4 is implicated in drug resistance in breast cancer cell lines involving the regulation of energy-dependent transporter expression
  publication-title: Biochem Pharmacol
  doi: 10.1016/J.BCP.2018.11.005
  contributor:
    fullname: Medrano
– volume: 18
  start-page: 100
  year: 2004
  end-page: 106
  ident: CR49
  article-title: Characterization of triacsin C inhibition of short-, medium-, and long-chain fatty acid: CoA ligases of human liver
  publication-title: J Biochem Mol Toxicol
  doi: 10.1002/jbt.20009
  contributor:
    fullname: Warren
– volume: 256
  start-page: 179
  year: 1981
  end-page: 183
  ident: CR26
  article-title: Regulation of gonadotropin receptors and gonadotropin responses in a clonal strain of Leydig tumor cells by epidermal growth factor
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(19)70116-1
  contributor:
    fullname: Ascoli
– volume: 8
  start-page: 1
  year: 2018
  end-page: 13
  ident: CR60
  article-title: Molecular mechanisms and emerging therapeutic targets of triple-negative breast cancer metastasis
  publication-title: Front Oncol
  doi: 10.3389/fonc.2018.00031
  contributor:
    fullname: Papageorgis
– volume: 273
  start-page: 5011
  year: 2006
  end-page: 5021
  ident: CR29
  article-title: cAMP increases mitochondrial cholesterol transport through the induction of arachidonic acid release inside this organelle in Leydig cells
  publication-title: FEBS J
  doi: 10.1111/j.1742-4658.2006.05496.x
  contributor:
    fullname: Castilla
– volume: 68
  start-page: 394
  year: 2018
  end-page: 424
  ident: CR1
  article-title: Global cancer statistics 2018: GLOBOCAN. A cancer
  publication-title: J Clin
  doi: 10.3322/caac.21492
  contributor:
    fullname: Soerjomataram
– volume: 7
  start-page: 1
  year: 2016
  end-page: 15
  ident: CR19
  article-title: Role of protein phosphorylation and tyrosine phosphatases in the adrenal regulation of steroid synthesis and mitochondrial function
  publication-title: Front Endocrinol
  doi: 10.3389/fendo.2016.00060
  contributor:
    fullname: Gorostizaga
– volume: 3
  start-page: 1994
  year: 1964
  end-page: 1998
  ident: CR53
  article-title: The stimulation of pregnenolone synthesis in the large particles from rat adrenals by some agents which cause mitochondrial swelling
  publication-title: Biochemistry
  doi: 10.1021/bi00900a036
  contributor:
    fullname: Koritz
– volume: 1838
  start-page: 2600
  year: 2014
  end-page: 2606
  ident: CR54
  article-title: Ca2 +-dependent permeabilization of mitochondria and liposomes by palmitic and oleic acids: a comparative study
  publication-title: Biochim Biophys Acta Biomembr
  doi: 10.1016/j.bbamem.2014.06.017
  contributor:
    fullname: Agafonov
– volume: 8
  start-page: 243
  year: 2017
  end-page: 256
  ident: CR25
  article-title: Role of 20-hydroxyeicosatetraenoic acid (20-HETE) in androgen-mediated cell viability in prostate cancer cells
  publication-title: Horm Cancer
  doi: 10.1007/s12672-017-0299-0
  contributor:
    fullname: Sacca
– volume: 378
  start-page: 645
  year: 2018
  end-page: 657
  ident: CR4
  article-title: Metastatic prostate cancer
  publication-title: N Engl J Med
  doi: 10.1056/NEJMra1701695
  contributor:
    fullname: de Bono
– volume: 279
  start-page: 31717
  year: 2004
  end-page: 31726
  ident: CR39
  article-title: Structural basis of the substrate-specific two-step catalysis of long chain fatty acyl-CoA synthetase dimer
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M400100200
  contributor:
    fullname: Nakagawa
– volume: 29
  start-page: 1235
  year: 2018
  end-page: 1248
  ident: CR59
  article-title: Adding abiraterone or docetaxel to long-term hormone therapy for prostate cancer: directly randomised data from the STAMPEDE multi-arm, multi-stage platform protocol
  publication-title: Ann Oncol
  doi: 10.1093/annonc/mdy072
  contributor:
    fullname: Mason
– volume: 32
  start-page: 81
  year: 2011
  end-page: 151
  ident: CR64
  article-title: The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders
  publication-title: Endocr Rev
  doi: 10.1210/er.2010-0013
  contributor:
    fullname: Auchus
– volume: 135
  start-page: 865
  year: 2009
  end-page: 877
  ident: CR36
  article-title: Developmental programming: prenatal androgen excess disrupts ovarian steroid receptor balance
  publication-title: Reproduction
  doi: 10.1530/REP-08-0491
  contributor:
    fullname: Padmanabhan
– volume: 471
  start-page: 108
  year: 2000
  end-page: 112
  ident: CR52
  article-title: Long-chain fatty acid-promoted swelling of mitochondria: Further evidence for the protonophoric effect of fatty acids in the inner mitochondrial membrane
  publication-title: FEBS Lett
  doi: 10.1016/S0014-5793(00)01376-4
  contributor:
    fullname: Wojtczak
– volume: 3
  start-page: 91
  year: 2010
  end-page: 98
  ident: CR11
  article-title: Expression of long-chain fatty acyl-coa synthetase 4 in breast and prostate cancers is associated with sex steroid hormone receptor negativity
  publication-title: Transl Oncol
  doi: 10.1593/tlo.09202
  contributor:
    fullname: Lee
– volume: 15
  start-page: 1
  year: 2019
  end-page: 16
  ident: CR61
  article-title: Targeting long chain acyl-coa synthetases for cancer therapy
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms20153624
  contributor:
    fullname: Konstantinidou
– volume: 7
  start-page: 149
  year: 2016
  end-page: 164
  ident: CR21
  article-title: The metabolism, analysis, and targeting of steroid hormones in breast and prostate cancer
  publication-title: Horm Cancer
  doi: 10.1007/s12672-016-0259-0
  contributor:
    fullname: Auchus
– volume: 1771
  start-page: 663
  year: 2007
  end-page: 676
  ident: CR63
  article-title: Steroidogenic acute regulatory protein (StAR), a novel mitochondrial cholesterol transporter
  publication-title: Biochim Biophys Acta Mol Cell Biol Lipids
  doi: 10.1016/j.bbalip.2007.02.012
  contributor:
    fullname: Miller
– volume: 65
  start-page: 109422
  year: 2020
  ident: CR58
  article-title: LncRNA NEAT1 promotes docetaxel resistance in prostate cancer by regulating ACSL4 via sponging miR-34a-5p and miR-204–5p
  publication-title: Cell Signal
  doi: 10.1016/j.cellsig.2019.109422
  contributor:
    fullname: Zhang
– volume: 272
  start-page: 1804
  year: 2005
  end-page: 1814
  ident: CR18
  article-title: Silencing the expression of mitochondrial acyl-CoA thioesterase I and acyl-CoA synthetase 4 inhibits hormone-induced steroidogenesis
  publication-title: FEBS J
  doi: 10.1111/j.1742-4658.2005.04616.x
  contributor:
    fullname: Castillo
– volume: 144
  start-page: 436
  year: 2014
  end-page: 444
  ident: CR48
  article-title: Next-generation steroidogenesis inhibitors, dutasteride and abiraterone, attenuate but still do not eliminate androgen biosynthesis in 22RV1 cells in vitro
  publication-title: J Steroid Biochem Mol Biol
  doi: 10.1016/j.jsbmb.2014.09.004
  contributor:
    fullname: Ming
– volume: 8
  start-page: 1
  year: 2013
  end-page: 20
  ident: CR13
  article-title: Long chain fatty Acyl-CoA synthetase 4 is a biomarker for and mediator of hormone resistance in human breast cancer
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0077060
  contributor:
    fullname: Wang
– volume: 12
  start-page: 3492
  year: 2015
  end-page: 3498
  ident: CR41
  article-title: Long-chain acyl-CoA synthetase in fatty acid metabolism involved in liver and other diseases: an update
  publication-title: World J Gastroenterol
  doi: 10.3748/wjg.v21.i12.3492
  contributor:
    fullname: Liu
– volume: 5
  start-page: 1
  year: 2010
  end-page: 12
  ident: CR6
  article-title: Functional interaction between acyl-coa synthetase 4, lipoxygenases and cyclooxygenase-2 in the aggressive phenotype of breast cancer cells
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0015540
  contributor:
    fullname: Orlando
– volume: 76
  start-page: 1896
  year: 2006
  end-page: 1900
  ident: CR27
  article-title: Mutations in cyclic AMP-dependent protein kinase and corticotropin (ACTH)-sensitive adenylate cyclase affect adrenal steroidogenesis
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.76.4.1896
  contributor:
    fullname: Schimmer
– volume: 163
  start-page: 506
  year: 2015
  end-page: 519
  ident: CR37
  article-title: Comprehensive molecular portraits of invasive lobular breast cancer
  publication-title: Cell
  doi: 10.1016/j.cell.2015.09.033
  contributor:
    fullname: Beck
– volume: 132
  start-page: 2123
  year: 2002
  end-page: 2126
  ident: CR42
  article-title: Do long-chain Acyl-CoA synthetases regulate fatty acid entry into synthetic versus degradative pathways?
  publication-title: J Nutr
  doi: 10.1093/jn/132.8.2123
  contributor:
    fullname: Gonzalez-Baró
– ident: CR7
– volume: 47
  start-page: 2004
  year: 2006
  end-page: 2010
  ident: CR44
  article-title: Rat long-chain acyl-CoA synthetase mRNA, protein, and activity vary in tissue distribution and in response to diet
  publication-title: J Lipid Res
  doi: 10.1194/jlr.M600150-JLR200
  contributor:
    fullname: Coleman
– volume: 1801
  start-page: 246
  year: 2010
  end-page: 251
  ident: CR45
  article-title: Acyl-CoA synthesis, lipid metabolism and lipotoxicity
  publication-title: Biochim Biophys Acta Mol Cell Biol Lipids
  doi: 10.1016/j.bbalip.2009.09.024
  contributor:
    fullname: Coleman
– volume: 89
  start-page: 956
  year: 2011
  end-page: 961
  ident: CR32
  article-title: Pharmacological relationship between nicotinic and opioid systems in analgesia and corticosterone elevation
  publication-title: Life Sci
  doi: 10.1016/j.lfs.2011.10.004
  contributor:
    fullname: Kobayashi
– ident: CR62
– volume: 5
  start-page: 459
  year: 2005
  end-page: 470
  ident: CR66
  article-title: Targeting steroid hormone receptor pathways in the treatment of hormone dependent cancers
  publication-title: Curr Pharm Biotechnol
  doi: 10.2174/1389201043376616
  contributor:
    fullname: Balk
– volume: 56
  start-page: 1143
  year: 2007
  end-page: 1152
  ident: CR40
  article-title: Rosiglitazone inhibits acyl-CoA synthetase activity and fatty acid partitioning to diacylglycerol and triacylglycerol via a peroxisome proliferator-activated receptor-gamma-independent mechanism in human arterial smooth muscle cells and macrophages
  publication-title: Diabetes
  doi: 10.2337/db06-0267
  contributor:
    fullname: Sherrid
– volume: 74
  start-page: 3228
  year: 2014
  end-page: 3237
  ident: CR38
  article-title: Global transcriptome analysis of formalin-fixed prostate cancer specimens identifies biomarkers of disease recurrence
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-13-2699
  contributor:
    fullname: Osunkoya
– volume: 269
  start-page: 5599
  year: 2002
  end-page: 5607
  ident: CR50
  article-title: Concerted regulation of free arachidonic acid and hormone-induced steroid synthesis by acyl-CoA thioesterases and acyl-CoA synthetases in adrenal cells
  publication-title: Eur J Biochem
  doi: 10.1046/j.1432-1033.2002.03267.x
  contributor:
    fullname: Mele
– volume: 89
  start-page: 956
  year: 2011
  ident: 3679_CR32
  publication-title: Life Sci
  doi: 10.1016/j.lfs.2011.10.004
  contributor:
    fullname: A Yamamoto
– ident: 3679_CR62
  doi: 10.18632/oncotarget.5340
– volume: 295
  start-page: 115
  year: 2008
  ident: 3679_CR65
  publication-title: Mol Cell Endocrinol
  doi: 10.1016/j.mce.2008.08.013
  contributor:
    fullname: PR Dillard
– volume: 25
  start-page: 5984
  year: 2019
  ident: 3679_CR67
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-18-3399
  contributor:
    fullname: A Kazi
– volume: 1801
  start-page: 246
  year: 2010
  ident: 3679_CR45
  publication-title: Biochim Biophys Acta Mol Cell Biol Lipids
  doi: 10.1016/j.bbalip.2009.09.024
  contributor:
    fullname: LO Li
– volume: 68
  start-page: 394
  year: 2018
  ident: 3679_CR1
  publication-title: J Clin
  doi: 10.3322/caac.21492
  contributor:
    fullname: F Bray
– volume: 269
  start-page: 28314
  year: 1994
  ident: 3679_CR56
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(18)46930-X
  contributor:
    fullname: BJ Clark
– ident: 3679_CR16
  doi: 10.1073/pnas.94.7.2880
– volume: 61
  start-page: 8429
  year: 2001
  ident: 3679_CR9
  publication-title: Cancer Res
  contributor:
    fullname: Y Cao
– volume: 256
  start-page: 179
  year: 1981
  ident: 3679_CR26
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(19)70116-1
  contributor:
    fullname: M Ascoli
– volume: 56
  start-page: 1143
  year: 2007
  ident: 3679_CR40
  publication-title: Diabetes
  doi: 10.2337/db06-0267
  contributor:
    fullname: B Askari
– volume: 256
  start-page: 5613
  year: 1979
  ident: 3679_CR30
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(18)50457-9
  contributor:
    fullname: F Chasalow
– volume: 132
  start-page: 2123
  year: 2002
  ident: 3679_CR42
  publication-title: J Nutr
  doi: 10.1093/jn/132.8.2123
  contributor:
    fullname: RA Coleman
– volume: 15
  start-page: 701
  year: 2015
  ident: 3679_CR69
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc4016
  contributor:
    fullname: PA Watson
– volume: 122
  start-page: 57
  year: 2008
  ident: 3679_CR34
  publication-title: Int J Cancer
  doi: 10.1002/ijc.23013
  contributor:
    fullname: Y Perera
– volume: 25
  start-page: 2607
  year: 2008
  ident: 3679_CR35
  publication-title: Anticancer Res
  contributor:
    fullname: GV Ripoll
– volume: 7
  start-page: 1
  year: 2012
  ident: 3679_CR10
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0040794
  contributor:
    fullname: UD Orlando
– volume: 80
  start-page: 702
  year: 1983
  ident: 3679_CR20
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.80.3.702
  contributor:
    fullname: CT Privalle
– volume: 269
  start-page: 5599
  year: 2002
  ident: 3679_CR50
  publication-title: Eur J Biochem
  doi: 10.1046/j.1432-1033.2002.03267.x
  contributor:
    fullname: P Maloberti
– volume: 276
  start-page: 24667
  year: 2001
  ident: 3679_CR28
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M010793200
  contributor:
    fullname: JH Kim
– volume: 33
  start-page: 1599
  year: 2015
  ident: 3679_CR33
  publication-title: Oncol Rep
  doi: 10.3892/or.2015.3746
  contributor:
    fullname: O Orellana-Serradell
– volume: 94
  start-page: 2880
  year: 1997
  ident: 3679_CR43
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.94.7.2880
  contributor:
    fullname: MJ Kang
– volume: 45
  start-page: 1958
  year: 2004
  ident: 3679_CR5
  publication-title: J Lipid Res
  doi: 10.1194/jlr.E400002-JLR200
  contributor:
    fullname: DG Mashek
– volume: 8
  start-page: 1
  year: 2013
  ident: 3679_CR13
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0077060
  contributor:
    fullname: X Wu
– volume: 5
  start-page: 459
  year: 2005
  ident: 3679_CR66
  publication-title: Curr Pharm Biotechnol
  doi: 10.2174/1389201043376616
  contributor:
    fullname: Y Ko
– volume: 1310
  start-page: 260
  year: 1996
  ident: 3679_CR31
  publication-title: Biochim Biophys Acta
  doi: 10.1016/0167-4889(95)00177-8
  contributor:
    fullname: PG Mele
– volume: 12
  start-page: 3492
  year: 2015
  ident: 3679_CR41
  publication-title: World J Gastroenterol
  doi: 10.3748/wjg.v21.i12.3492
  contributor:
    fullname: S Yan
– volume: 58
  start-page: 884
  year: 2017
  ident: 3679_CR46
  publication-title: J Lipid Res
  doi: 10.1194/jlr.M072512
  contributor:
    fullname: EL Klett
– volume: 3
  start-page: 1994
  year: 1964
  ident: 3679_CR53
  publication-title: Biochemistry
  doi: 10.1021/bi00900a036
  contributor:
    fullname: IN Hirshfield
– ident: 3679_CR7
  doi: 10.18632/oncotarget.6438
– volume: 94
  start-page: 421
  year: 2003
  ident: 3679_CR8
  publication-title: Cancer Sci
  doi: 10.1111/j.1349-7006.2003.tb01458.x
  contributor:
    fullname: YK Sung
– volume: 159
  start-page: 52
  year: 2019
  ident: 3679_CR14
  publication-title: Biochem Pharmacol
  doi: 10.1016/J.BCP.2018.11.005
  contributor:
    fullname: UD Orlando
– volume: 8
  start-page: 1
  year: 2018
  ident: 3679_CR60
  publication-title: Front Oncol
  doi: 10.3389/fonc.2018.00031
  contributor:
    fullname: C Neophytou
– volume: 3
  start-page: 91
  year: 2010
  ident: 3679_CR11
  publication-title: Transl Oncol
  doi: 10.1593/tlo.09202
  contributor:
    fullname: ME Monaco
– volume: 378
  start-page: 645
  year: 2018
  ident: 3679_CR4
  publication-title: N Engl J Med
  doi: 10.1056/NEJMra1701695
  contributor:
    fullname: O Sartor
– volume: 65
  start-page: 109422
  year: 2020
  ident: 3679_CR58
  publication-title: Cell Signal
  doi: 10.1016/j.cellsig.2019.109422
  contributor:
    fullname: X Jiang
– ident: 3679_CR12
  doi: 10.18632/oncotarget.5822
– volume: 135
  start-page: 865
  year: 2009
  ident: 3679_CR36
  publication-title: Reproduction
  doi: 10.1530/REP-08-0491
  contributor:
    fullname: HH Ortega
– volume: 74
  start-page: 3228
  year: 2014
  ident: 3679_CR38
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-13-2699
  contributor:
    fullname: Q Long
– volume: 15
  start-page: 1
  year: 2019
  ident: 3679_CR61
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms20153624
  contributor:
    fullname: MR Sebastiano
– volume: 52
  start-page: 1936
  year: 2011
  ident: 3679_CR47
  publication-title: J Lipid Res
  doi: 10.1194/jlr.M015552
  contributor:
    fullname: M Cooke
– volume: 7
  start-page: 1
  year: 2016
  ident: 3679_CR19
  publication-title: Front Endocrinol
  doi: 10.3389/fendo.2016.00060
  contributor:
    fullname: C Paz
– volume: 5
  start-page: 1
  year: 2010
  ident: 3679_CR6
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0015540
  contributor:
    fullname: PM Maloberti
– volume: 471
  start-page: 108
  year: 2000
  ident: 3679_CR52
  publication-title: FEBS Lett
  doi: 10.1016/S0014-5793(00)01376-4
  contributor:
    fullname: P Schönfeld
– volume: 1771
  start-page: 663
  year: 2007
  ident: 3679_CR63
  publication-title: Biochim Biophys Acta Mol Cell Biol Lipids
  doi: 10.1016/j.bbalip.2007.02.012
  contributor:
    fullname: WL Miller
– volume: 34
  start-page: 655
  year: 2005
  ident: 3679_CR17
  publication-title: J Mol Endocrinol
  doi: 10.1677/jme.1.01691
  contributor:
    fullname: F Cornejo Maciel
– volume: 163
  start-page: 506
  year: 2015
  ident: 3679_CR37
  publication-title: Cell
  doi: 10.1016/j.cell.2015.09.033
  contributor:
    fullname: G Ciriello
– volume: 144
  start-page: 436
  year: 2014
  ident: 3679_CR48
  publication-title: J Steroid Biochem Mol Biol
  doi: 10.1016/j.jsbmb.2014.09.004
  contributor:
    fullname: S Pham
– volume: 98
  start-page: 10869
  year: 2001
  ident: 3679_CR3
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.191367098
  contributor:
    fullname: T Sorlie
– volume: 47
  start-page: 2004
  year: 2006
  ident: 3679_CR44
  publication-title: J Lipid Res
  doi: 10.1194/jlr.M600150-JLR200
  contributor:
    fullname: DG Mashek
– volume: 36
  start-page: 2731
  year: 2016
  ident: 3679_CR68
  publication-title: Oncol Rep
  doi: 10.3892/or.2016.5094
  contributor:
    fullname: RG Armando
– volume: 79
  start-page: 3320
  year: 2019
  ident: 3679_CR55
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-18-2529
  contributor:
    fullname: JA Gordon
– volume: 8
  start-page: 243
  year: 2017
  ident: 3679_CR25
  publication-title: Horm Cancer
  doi: 10.1007/s12672-017-0299-0
  contributor:
    fullname: C Colombero
– volume: 279
  start-page: 31717
  year: 2004
  ident: 3679_CR39
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M400100200
  contributor:
    fullname: Y Hisanaga
– volume: 76
  start-page: 1896
  year: 2006
  ident: 3679_CR27
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.76.4.1896
  contributor:
    fullname: PA Rae
– volume: 37
  start-page: 258
  issue: 2
  year: 2020
  ident: 3679_CR24
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2020.01.010
  contributor:
    fullname: DR Sudhan
– volume: 18
  start-page: 100
  year: 2004
  ident: 3679_CR49
  publication-title: J Biochem Mol Toxicol
  doi: 10.1002/jbt.20009
  contributor:
    fullname: DA Vessey
– volume: 272
  start-page: 1804
  year: 2005
  ident: 3679_CR18
  publication-title: FEBS J
  doi: 10.1111/j.1742-4658.2005.04616.x
  contributor:
    fullname: P Maloberti
– volume: 49
  start-page: 399
  year: 2017
  ident: 3679_CR51
  publication-title: J Bioenerg Biomembr
  doi: 10.1007/s10863-017-9725-9
  contributor:
    fullname: CRP Dechandt
– volume: 7
  start-page: 149
  year: 2016
  ident: 3679_CR21
  publication-title: Horm Cancer
  doi: 10.1007/s12672-016-0259-0
  contributor:
    fullname: CP Capper
– volume: 406
  start-page: 747
  year: 2000
  ident: 3679_CR2
  publication-title: Nature
  doi: 10.1038/35021093
  contributor:
    fullname: CM Perou
– volume: 32
  start-page: 81
  year: 2011
  ident: 3679_CR64
  publication-title: Endocr Rev
  doi: 10.1210/er.2010-0013
  contributor:
    fullname: WL Miller
– volume: 1838
  start-page: 2600
  year: 2014
  ident: 3679_CR54
  publication-title: Biochim Biophys Acta Biomembr
  doi: 10.1016/j.bbamem.2014.06.017
  contributor:
    fullname: K Belosludtsev
– volume: 273
  start-page: 5011
  year: 2006
  ident: 3679_CR29
  publication-title: FEBS J
  doi: 10.1111/j.1742-4658.2006.05496.x
  contributor:
    fullname: AF Castillo
– volume: 29
  start-page: 1235
  year: 2018
  ident: 3679_CR59
  publication-title: Ann Oncol
  doi: 10.1093/annonc/mdy072
  contributor:
    fullname: MR Sydes
– volume: 115
  start-page: 1069
  year: 2016
  ident: 3679_CR22
  publication-title: Br J Cancer
  doi: 10.1038/bjc.2016.294
  contributor:
    fullname: A Courtin
– volume: 63
  start-page: 193
  year: 2001
  ident: 3679_CR57
  publication-title: Annu Rev Physiol
  doi: 10.1146/annurev.physiol.63.1.193
  contributor:
    fullname: DM Stocco
– volume: 3
  start-page: 1
  year: 2016
  ident: 3679_CR15
  publication-title: Transcr Open Access
  doi: 10.4172/2329-8936.1000120
  contributor:
    fullname: AF Castillo
– volume: 83
  start-page: 37
  year: 2014
  ident: 3679_CR23
  publication-title: Lung Cancer
  doi: 10.1016/j.lungcan.2013.09.019
  contributor:
    fullname: N Yamaguchi
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Snippet Acyl-CoA synthetase 4 (ACSL4) is an isoenzyme of the fatty acid ligase-coenzyme-A family taking part in arachidonic acid metabolism and steroidogenesis. ACSL4...
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SubjectTerms Animal models
Animals
Arachidonic acid
Binding Sites
Biochemistry
Bioinformatics
Biomedical and Life Sciences
Biomedicine
Breast cancer
Breast Neoplasms - drug therapy
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cancer
Cell Biology
Cell culture
Cell Line, Tumor
Cell Movement - drug effects
Cell proliferation
Cell Proliferation - drug effects
Coenzyme A Ligases - antagonists & inhibitors
Coenzyme A Ligases - metabolism
Drug resistance
Drug Resistance, Neoplasm
Enzyme Inhibitors - metabolism
Enzyme Inhibitors - pharmacology
Enzyme Inhibitors - therapeutic use
Fatty acids
Female
Gene expression
Homology
Humans
Life Sciences
Male
Mass spectroscopy
Mice
Mice, Inbred BALB C
Mice, Nude
Molecular Docking Simulation
NMR
Nuclear magnetic resonance
Original
Original Article
Prostate
Prostate - cytology
Prostate - metabolism
Prostate cancer
Prostatic Neoplasms - metabolism
Prostatic Neoplasms - pathology
Signal transduction
Steroidogenesis
Steroids
Steroids - blood
Synthesis
Tumor cells
Tumors
Xenograft Model Antitumor Assays
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Title New inhibitor targeting Acyl-CoA synthetase 4 reduces breast and prostate tumor growth, therapeutic resistance and steroidogenesis
URI https://link.springer.com/article/10.1007/s00018-020-03679-5
https://www.ncbi.nlm.nih.gov/pubmed/33068124
https://www.proquest.com/docview/2505799638
https://search.proquest.com/docview/2451862428
https://pubmed.ncbi.nlm.nih.gov/PMC11072814
Volume 78
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