Effects of vitamin D supplementation on bone turnover markers and other bone-related substances in subjects with vitamin D deficiency

• Published in: Bone (New York, N.Y.) Vol. 124; pp. 7 - 13
• Main Authors: Jorde, Rolf, Stunes, Astrid Kamilla, Kubiak, Julia, Joakimsen, Ragnar, Grimnes, Guri, Thorsby, Per Medbøe, Syversen, Unni
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2019; Elsevier
• Subjects: Basale medisinske, odontologiske og veterinærmedisinske fag: 710; Basic medical, dental and veterinary science disciplines: 710; Bone turnover; CTX-1; Medical disciplines: 700; Medisinske Fag: 700; P1NP; PTH; VDP; Vitamin D; RANKL; PTH; VDR; P1NP; BTMs; OPG; 1,25(OH)2D; Bone turnover; DXA; DKK1; TNF-α; Vitamin D; RCTs; BMD; 25(OH)D; CTX-1; FGF23; BMI
• ISSN: 8756-3282; 1873-2763; 1873-2763
• DOI: 10.1016/j.bone.2019.04.002

In observational studies, vitamin D deficiency is a risk factor for low bone density and future fractures, whereas a causal relation has been difficult to show in randomized controlled trials (RCTs). Similarly, vitamin D deficiency has been associated with increased bone turnover, but RCTs with vita...