Connectivity based on glucose dynamics reveals exaggerated sensorimotor network coupling on subject-level in Parkinson’s disease

• Published in: European journal of nuclear medicine and molecular imaging Vol. 51; no. 12; pp. 3630 - 3642
• Main Authors: Ruppert-Junck, Marina C., Heinecke, Vanessa, Librizzi, Damiano, Steidel, Kenan, Beckersjürgen, Maya, Verburg, Frederik A., Schurrat, Tino, Luster, Markus, Müller, Hans-Helge, Timmermann, Lars, Eggers, Carsten, Pedrosa, David
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2024; Springer Nature B.V
• Subjects: Aged; Biomarkers; Blood levels; Brain; Cardiology; Case-Control Studies; Cognition; Coupling; Female; Fluorine isotopes; Fluorodeoxyglucose F18; Functional magnetic resonance imaging; Glucose; Glucose - metabolism; Hemodynamics; Humans; Imaging; Independent component analysis; Magnetic Resonance Imaging; Male; Medicine; Medicine & Public Health; Metabolic networks; Metabolism; Middle Aged; Motor task performance; Movement disorders; Nerve Net - diagnostic imaging; Nerve Net - physiopathology; Neural networks; Neurodegeneration; Neurodegenerative diseases; Nuclear Medicine; Oncology; Original; Original Article; Orthopedics; Oxygenation; Parkinson Disease - diagnostic imaging; Parkinson Disease - metabolism; Parkinson Disease - physiopathology; Parkinson's disease; Positron emission; Positron emission tomography; Radiology; Sensorimotor system; F]-Fluorodeoxyglucose-PET; Dynamic; Network degeneration; Metabolic connectivity; Imaging biomarker; Multimodal connectome; Glucose Dynamics; Dynamic [18F]-Fluorodeoxyglucose-PET

Purpose While fMRI provides information on the temporal changes in blood oxygenation, 2- [18F]fluoro-2-deoxy-D-glucose ([ 18 F]FDG)-PET has traditionally offered a static snapshot of brain glucose consumption. As a result, studies investigating metabolic brain networks as potential biomarkers for ne...