BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility

• Published in: Nature microbiology Vol. 9; no. 1; pp. 120 - 135
• Main Authors: Amaral, Eduardo P., Namasivayam, Sivaranjani, Queiroz, Artur T. L., Fukutani, Eduardo, Hilligan, Kerry L., Aberman, Kate, Fisher, Logan, Bomfim, Caio Cesar B., Kauffman, Keith, Buchanan, Jay, Santuo, Leslie, Gazzinelli-Guimaraes, Pedro Henrique, Costa, Diego L., Teixeira, Mariane Araujo, Barreto-Duarte, Beatriz, Rocha, Clarissa Gurgel, Santana, Monique Freire, Cordeiro-Santos, Marcelo, Barber, Daniel L., Wilkinson, Robert J., Kramnik, Igor, Igarashi, Kazuhiko, Scriba, Thomas, Mayer-Barber, Katrin D., Andrade, Bruno B., Sher, Alan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.01.2024; Nature Publishing Group
• Subjects: 13/1; 13/106; 13/21; 13/31; 13/51; 14/63; 38/77; 38/91; 631/250/1933; 631/250/255/1856; 631/80/82; 82/51; Animals; Antioxidants; Basic-Leucine Zipper Transcription Factors - genetics; Biomedical and Life Sciences; Cell death; Cell survival; Ferroptosis; Glutathione; Infectious Diseases; Life Sciences; Lipid peroxidation; Lipids; Macrophages; Macrophages - microbiology; Medical Microbiology; Mice; Microbiology; Mycobacterium tuberculosis; Mycobacterium tuberculosis - genetics; Necrosis; Oxidative stress; Parasitology; Pathogenesis; Transcription factors; Tuberculosis; Tuberculosis - microbiology; Tuberculosis, Pulmonary - genetics; Virology

Oxidative stress triggers ferroptosis, a form of cellular necrosis characterized by iron-dependent lipid peroxidation, and has been implicated in Mycobacterium tuberculosis (Mtb) pathogenesis. We investigated whether Bach1, a transcription factor that represses multiple antioxidant genes, regulates...