Neural population dynamics in human motor cortex during movements in people with ALS

• Published in: eLife Vol. 4; p. e07436
• Main Authors: Pandarinath, Chethan, Gilja, Vikash, Blabe, Christine H, Nuyujukian, Paul, Sarma, Anish A, Sorice, Brittany L, Eskandar, Emad N, Hochberg, Leigh R, Henderson, Jaimie M, Shenoy, Krishna V
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications Ltd 23.06.2015; eLife Sciences Publications, Ltd
• Subjects: Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - pathology; Amyotrophic Lateral Sclerosis - physiopathology; Clinical trials; computational neuroscience; Cortex (motor); Cortex (temporal); dynamical system; Dynamical systems; Eigenvalues; Human Biology and Medicine; Humans; Models, Neurological; motor control; motor cortex; Motor Cortex - physiology; Movement; Neural Pathways - physiology; Neurons - physiology; Neuroscience; Neurosciences; Neurosurgery; Population; Principal components analysis; Short Report; United States > US; human biology; dynamical systems; motor cortex; neuroscience; medicine; computational neuroscience; human; motor control

The prevailing view of motor cortex holds that motor cortical neural activity represents muscle or movement parameters. However, recent studies in non-human primates have shown that neural activity does not simply represent muscle or movement parameters; instead, its temporal structure is well-descr...