POMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels

• Published in: eLife Vol. 7
• Main Authors: Caron, Alexandre, Dungan Lemko, Heather M, Castorena, Carlos M, Fujikawa, Teppei, Lee, Syann, Lord, Caleb C, Ahmed, Newaz, Lee, Charlotte E, Holland, William L, Liu, Chen, Elmquist, Joel K
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications Ltd 12.03.2018; eLife Sciences Publications, Ltd
• Subjects: Adaptations; Adipocytes; ADRA2A; Adrenergic receptors; Animals; Body fat; Diabetes; Eating - genetics; Energy; Energy balance; Energy Metabolism - genetics; Fasting; Fasting - metabolism; Food intake; Gene expression; Glucose; Glucose - genetics; Glucose - metabolism; Glucose homeostasis; Homeostasis; Homeostasis - genetics; Human Biology and Medicine; Humans; Internal medicine; Laboratory testing; leptin; Leptin - genetics; Leptin - metabolism; Leptin receptors; Metabolism; Mice; Neurons; Neurons - metabolism; Neuroscience; NMR; Nuclear magnetic resonance; Obesity; POMC; Pro-Opiomelanocortin - genetics; Pro-Opiomelanocortin - metabolism; Proopiomelanocortin; Receptors, Adrenergic, alpha-2 - genetics; Receptors, Leptin - genetics; Receptors, Leptin - metabolism; Rodents; Secretion; Spectrum analysis; Starvation; Sympathetic nervous system; Sympathetic Nervous System - metabolism; United States > US; POMC; human biology; mouse; Glucose homeostasis; neuroscience; fasting; medicine; leptin; ADRA2A

Leptin is critical for energy balance, glucose homeostasis, and for metabolic and neuroendocrine adaptations to starvation. A prevalent model predicts that leptin’s actions are mediated through pro-opiomelanocortin (POMC) neurons that express leptin receptors (LEPRs). However, previous studies have...