POMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels - Caron, Alexandre; Dungan Lemko, Heather M; Castorena, Carlos M; Fujikawa, Teppei; Lee, Syann; Lord, Caleb C; Ahmed, Newaz; Lee, Charlotte E; Holland, William L; Liu, Chen; Elmquist, Joel K (eLife, 2018)
Keywords: Adaptations; Adipocytes; ADRA2A; Adrenergic receptors; Animals; Body fat; Diabetes; Eating - genetics; Energy; Energy balance; Energy Metabolism - genetics; Fasting; Fasting - metabolism; Food intake; Gene expression; Glucose; Glucose - genetics; Glucose - metabolism; Glucose homeostasis; Homeostasis; Homeostasis - genetics; Human Biology and Medicine; Humans; Internal medicine; Laboratory testing; leptin; Leptin - genetics; Leptin - metabolism; Leptin receptors; Metabolism; Mice; Neurons; Neurons - metabolism; Neuroscience; NMR; Nuclear magnetic resonance; Obesity; POMC; Pro-Opiomelanocortin - genetics; Pro-Opiomelanocortin - metabolism; Proopiomelanocortin; Receptors, Adrenergic, alpha-2 - genetics; Receptors, Leptin - genetics; Receptors, Leptin - metabolism; Rodents; Secretion; Spectrum analysis; Starvation; Sympathetic nervous system; Sympathetic Nervous System - metabolism; United States--US; POMC; human biology; mouse; Glucose homeostasis; neuroscience; fasting; medicine; leptin; ADRA2A