Estimation of FMO3 Ontogeny by Mechanistic Population Pharmacokinetic Modelling of Risdiplam and Its Impact on Drug–Drug Interactions in Children - Cleary, Yumi; Kletzl, Heidemarie; Grimsey, Paul; Heinig, Katja; Ogungbenro, Kayode; Silber Baumann, Hanna Elisabeth; Frey, Nicolas; Aarons, Leon; Galetin, Aleksandra; Gertz, Michael (Clinical pharmacokinetics, 2023)
Keywords: Adult; Adults; Age; Bioavailability; Child; Cytochrome; Cytochrome P-450 CYP3A - metabolism; Drug Interactions; Enzymes; Humans; Infant; Internal Medicine; Investigations; Medicine; Medicine & Public Health; Metabolism; Models, Biological; NCT; NCT02633709; NCT02908685; NCT02913482; NCT03032172; NCT03988907; Neuromuscular diseases; Original; Original Research Article; Parameter estimation; Pediatrics; Pharmacokinetics; Pharmacology/Toxicology; Pharmacotherapy; Prospective Studies; Proteins