Redox stress unbalances the inflammatory cytokine network: role in autoinflammatory patients and healthy subjects

• Published in: Journal of leukocyte biology Vol. 99; no. 1; pp. 79 - 86
• Main Authors: Lavieri, Rosa, Rubartelli, Anna, Carta, Sonia
• Format: Journal Article
• Language: English
• Published: United States Society for Leukocyte Biology 01.01.2016
• Subjects: Adenosine Triphosphate - metabolism; Animals; ATP secretion; Autoimmune Diseases - immunology; Autoimmune Diseases - metabolism; Cryopyrin-Associated Periodic Syndromes - immunology; Cryopyrin-Associated Periodic Syndromes - metabolism; Cytokines - biosynthesis; Cytokines - metabolism; Healthy Volunteers; Humans; Inflammasomes - immunology; Inflammasomes - metabolism; Inflammation - immunology; Inflammation - metabolism; Inflammation Mediators - metabolism; Interleukin 1 Receptor Antagonist Protein - metabolism; Interleukin-1beta - metabolism; interleukin‐1 family; Monocytes - immunology; Monocytes - metabolism; NLRP3 inflammasome; Oxidation-Reduction; Oxidative Stress; Reviews; Signal Transduction; TLR agonist; interleukin-1 family; NLRP3 inflammasome; ATP secretion; TLR agonist
• ISSN: 0741-5400; 1938-3673
• DOI: 10.1189/jlb.3MR0415-159R

Review on the interplay between stress and cytokine dysregulation in inflammation, in both healthy individuals and CAPS patients. The cell stress and redox responses are increasingly acknowledged as factors contributing to the generation and development of the inflammatory response. Several inflamma...