Multi‐omic analysis in normal colon organoids highlights MSH4 as a novel marker of defective mismatch repair in Lynch syndrome and microsatellite instability - Devall, Matthew; Ali, Mourad W.; Eaton, Stephen; Weisenberger, Daniel J.; Reilley, Matthew J.; Powell, Steven M.; Li, Li; Casey, Graham (Cancer medicine (Malden, MA), 2023)
Keywords: Biomarkers, Tumor - genetics; Biopsy; Bisulfite; Cancer; Cell Cycle Proteins - genetics; Colon; colon organoids; Colorectal cancer; Colorectal Neoplasms, Hereditary Nonpolyposis - genetics; Colorectal Neoplasms, Hereditary Nonpolyposis - pathology; CRISPR; DNA methylation; DNA microarrays; DNA Mismatch Repair - genetics; Endometrium; Gene expression; Genes; Genetic disorders; Genomics; Humans; Lynch syndrome; Microsatellite Instability; Mismatch repair; MLH1 protein; MSH2 protein; MSH6 protein; Multiomics; Mutation; Organoids; Penicillin; R&D; Research & development; Surveillance; Tumors; Yeast; United States--US; colon organoids; microsatellite instability; colorectal cancer; Lynch syndrome