MicroRNA‐204 Regulates Runx2 Protein Expression and Mesenchymal Progenitor Cell Differentiation

• Published in: Stem cells (Dayton, Ohio) Vol. 28; no. 2; pp. 357 - 364
• Main Authors: Huang, Jian, Zhao, Lan, Xing, Lianping, Chen, Di
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.02.2010
• Subjects: Adipocyte; Animals; Blotting, Western; Cell Differentiation - genetics; Cell Differentiation - physiology; Cell Line; Core Binding Factor Alpha 1 Subunit - genetics; Core Binding Factor Alpha 1 Subunit - metabolism; Mesenchymal stem cells; Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - metabolism; Mice; MicroRNAs - genetics; MicroRNAs - physiology; miR‐204; Osteoblast; Reverse Transcriptase Polymerase Chain Reaction; Runx2

Differentiation of mesenchymal stem cells into a particular lineage is tightly regulated, and malfunction of this regulation could lead to pathological consequences. Patients with osteoporosis have increased adipocyte accumulation, but the mechanisms involved remain to be defined. In this study, we...