Alteration in Indole Metabolites After Cardiopulmonary Bypass Surgery in Neonates and Infants

• Published in: Critical care explorations Vol. 7; no. 5; p. e1267
• Main Authors: Leroue, Matthew K., Maddux, Aline B., Lehmann, Tanner, Niemiec, Sierra, Mancuso, Christopher A., Khailova, Ludmila, Mourani, Peter M., Klawitter, Jelena, Davidson, Jesse A.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 05.05.2025; Wolters Kluwer
• Subjects: Cardiopulmonary Bypass - adverse effects; Female; Gastrointestinal Microbiome - physiology; Humans; Indoleacetic Acids - blood; Indoles - blood; Indoles - metabolism; Infant; Infant, Newborn; Length of Stay - statistics & numerical data; Male; Observational Study; Prospective Studies; enteral nutrition; cardiopulmonary bypass; indoles; tryptophan; indole-3-carboxylic acid

IMPORTANCE: Cardiopulmonary bypass (CPB) surgery is associated with changes in the intestinal microbiome. Metabolism of tryptophan into the indole pathway is entirely facilitated by the intestinal microbiome, and indole metabolites play a critical role in intestinal epithelial integrity, intestinal...