Walking performance is positively correlated to calf muscle fiber size in peripheral artery disease subjects, but fibers show aberrant mitophagy: an observational study - White, Sarah H.; McDermott, Mary M.; Sufit, Robert L.; Kosmac, Kate; Bugg, Alex W.; Gonzalez-Freire, Marta; Ferrucci, Luigi; Tian, Lu; Zhao, Lihui; Gao, Ying; Kibbe, Melina R.; Criqui, Michael H.; et al. (Journal of translational medicine, 2016)
Keywords: Aged; Capillaries - pathology; Complications and side effects; Female; Humans; Male; Microtubule-Associated Proteins - metabolism; Mitochondria - metabolism; Mitochondrial Degradation; Muscle Fibers, Skeletal - metabolism; Muscle Fibers, Skeletal - pathology; Neurofibrils; Oxidation-Reduction; Peripheral Arterial Disease - metabolism; Peripheral Arterial Disease - pathology; Peripheral Arterial Disease - physiopathology; Peripheral vascular diseases; Physiological aspects; RNA, Messenger - genetics; RNA, Messenger - metabolism; Succinate Dehydrogenase - metabolism; Walking - physiology; United States; Peripheral artery disease; Mitochondria; Calf muscle; Mitophagy; Fiber type