Complement modulation of T cell immune responses during homeostasis and disease

• Published in: Journal of leukocyte biology Vol. 96; no. 5; pp. 745 - 756
• Main Authors: Clarke, Elizabeth V., Tenner, Andrea J.
• Format: Journal Article
• Language: English
• Published: United States Society for Leukocyte Biology 01.11.2014
• Subjects: Animals; C1q; C5a; CD46; CD55 Antigens - genetics; CD55 Antigens - immunology; CD55 Antigens - metabolism; Complement C1q - genetics; Complement C1q - immunology; Complement C1q - metabolism; Complement C3 - genetics; Complement C3 - immunology; Complement C3 - metabolism; Complement C5a - genetics; Complement C5a - immunology; Complement C5a - metabolism; Complement System Proteins - genetics; Complement System Proteins - immunology; Complement System Proteins - metabolism; DAF; Homeostasis - genetics; Homeostasis - immunology; Humans; Immunomodulation; Membrane Cofactor Protein - genetics; Membrane Cofactor Protein - immunology; Membrane Cofactor Protein - metabolism; Reviews; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; C3; DAF; C1q; CD46; C5a

Review on the influence of complement proteins, activation fragments, and regulatory receptors on T cell function, noting differences between humans and mice. The complement system is an ancient and critical effector mechanism of the innate immune system as it senses, kills, and clears infectious an...