A novel framework to build saliva‐based DNA methylation biomarkers: Quantifying systemic chronic inflammation as a case study

• Published in: Aging cell Vol. 24; no. 4; pp. e14444 - n/a
• Main Authors: Schmunk, Lisa J., Call, Toby P., McCartney, Daniel L., Javaid, Hira, Hastings, Waylon J., Jovicevic, Vanja, Kojadinović, Dragoljub, Tomkinson, Natacha, Zlamalova, Eliska, McGee, Kirsty C., Sullivan, Jack, Campbell, Archie, McIntosh, Andrew M., Óvári, Veronika, Wishart, Karl, Behrens, Christian E., Stone, Emma, Gavrilov, Miloš, Thompson, Rob, Jackson, Thomas, Lord, Janet M., Stubbs, Thomas M., Marioni, Riccardo E., Martin‐Herranz, Daniel E., Descamps, Pierric, Taylor, Emily, Paiusi, Chuck, Girr, Leona Mc, Philpott, Ollie, Robinson, Ian, Watson, Hector, Magalia, Ana, Russell, Dave, Woods, David
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.04.2025; John Wiley and Sons Inc
• Subjects: Adult; Aged; ageing; Aging; Aging - genetics; Biological markers; biomarker; Biomarkers; Biomarkers - metabolism; Blood; Blood proteins; C-reactive protein; Case studies; Chronic Disease; Datasets; Development and progression; DNA; DNA methylation; DNA Methylation - genetics; Electronic medical records; epigenetic clock; Epigenetic inheritance; Epigenetics; Female; Genetic research; Humans; Immunosenescence; inflammageing; Inflammation; Inflammation - genetics; Inflammation - metabolism; machine learning; Male; Medical records; Medicine, Preventive; Methylation; Middle Aged; Molecular modelling; Mortality; Preventive health services; Saliva; Saliva - metabolism; systemic chronic inflammation (SCI); ageing; DNA methylation; systemic chronic inflammation (SCI); biomarker; machine learning; inflammageing; epigenetic clock

Accessible and non‐invasive biomarkers that measure human ageing processes and the risk of developing age‐related disease are paramount in preventative healthcare. Here, we describe a novel framework to train saliva‐based DNA methylation (DNAm) biomarkers that are reproducible and biologically inter...