A novel framework to build saliva‐based DNA methylation biomarkers: Quantifying systemic chronic inflammation as a case study - Schmunk, Lisa J.; Call, Toby P.; McCartney, Daniel L.; Javaid, Hira; Hastings, Waylon J.; Jovicevic, Vanja; Kojadinović, Dragoljub; Tomkinson, Natacha; Zlamalova, Eliska; McGee, Kirsty C.; Sullivan, Jack; Campbell, Archie; et al. (Aging cell, 2025)
Keywords: Adult; Aged; ageing; Aging; Aging - genetics; Biological markers; biomarker; Biomarkers; Biomarkers - metabolism; Blood; Blood proteins; C-reactive protein; Case studies; Chronic Disease; Datasets; Development and progression; DNA; DNA methylation; DNA Methylation - genetics; Electronic medical records; epigenetic clock; Epigenetic inheritance; Epigenetics; Female; Genetic research; Humans; Immunosenescence; inflammageing; Inflammation; Inflammation - genetics; Inflammation - metabolism; machine learning; Male; Medical records; Medicine, Preventive; Methylation; Middle Aged; Molecular modelling; Mortality; Preventive health services; Saliva; Saliva - metabolism; systemic chronic inflammation (SCI); ageing; DNA methylation; systemic chronic inflammation (SCI); biomarker; machine learning; inflammageing; epigenetic clock