A common human TLR1 polymorphism regulates the innate immune response to lipopeptides

• Published in: European Journal of Immunology Vol. 37; no. 8; pp. 2280 - 2289
• Main Authors: Hawn, Thomas R., Misch, E. Ann, Dunstan, Sarah J., Thwaites, Guy E., Lan, Nguyen T. N., Quy, Hoang T., Chau, Tran T. H., Rodrigues, Stephanie, Nachman, Alex, Janer, Marta, Hien, Tran T., Farrar, Jeremy J., Aderem, Alan
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY‐VCH Verlag 01.08.2007
• Subjects: Bacterial Proteins - immunology; Base Sequence; Fluorescent Antibody Technique; Genetics; Humans; Immunity, Innate; Immunoblotting; Infectious diseases; Inflammation; Innate immunity; Lipoproteins - immunology; Mycobacterium tuberculosis; Mycobacterium tuberculosis - immunology; NF-kappa B; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Toll-Like Receptor 1 - genetics; Transfection

Toll‐like receptors (TLR) are critical mediators of the immune response to pathogens and human polymorphisms in this gene family regulate inflammatory pathways and are associated with susceptibility to infection. Lipopeptides are present in a wide variety of microbes and stimulate immune responses t...