Pancreatic cancer risk: Associations with meat-derived carcinogen intake in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort

• Published in: Molecular carcinogenesis Vol. 51; no. 1; pp. 128 - 137
• Main Authors: Anderson, Kristin E., Mongin, Steven J., Sinha, Rashmi, Stolzenberg-Solomon, Rachael, Gross, Myron D., Ziegler, Regina G., Mabie, Jerome E., Risch, Adam, Kazin, Sally S., Church, Timothy R.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.01.2012; Wiley Subscription Services, Inc
• Subjects: Aged; Amines - toxicity; Benzo(a)pyrene - toxicity; carcinogens; Carcinogens - toxicity; cohort; Colorectal Neoplasms - epidemiology; Colorectal Neoplasms - etiology; Cooking; Diet - adverse effects; Early Detection of Cancer; Female; Heterocyclic Compounds - toxicity; Hot Temperature - adverse effects; Humans; Lung Neoplasms - epidemiology; Lung Neoplasms - etiology; Male; Meat - adverse effects; meat intake; Middle Aged; Multicenter Studies as Topic; Ovarian cancer; Ovarian Neoplasms - epidemiology; Ovarian Neoplasms - etiology; Pancreatic cancer; Pancreatic Neoplasms - epidemiology; Pancreatic Neoplasms - etiology; Prostatic Neoplasms - epidemiology; Prostatic Neoplasms - etiology; Randomized Controlled Trials as Topic; Risk Factors

Background Epidemiological studies report positive associations between high‐temperature cooked meat intake and pancreatic cancer. We assessed associations between dietary intake of heterocyclic amines (HCAs) and benzo(a)pyrene (BaP)—mutagens formed in meat cooked at high temperatures—and incident e...