Diagnosis and treatment of chronic lymphocytic leukemia: recommendations from the Brazilian Group of Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia is characterized by clonal proliferation and progressive accumulation of B-cell lymphocytes that typically express CD19+, CD5+ and CD23+. The lymphocytes usually infiltrate the bone marrow, peripheral blood, lymph nodes, and spleen. The diagnosis is established by immuno...

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Published inRevista brasileira de hematologia e hemoterapia Vol. 38; no. 4; pp. 346 - 357
Main Authors Rodrigues, Celso Arrais, Gonçalves, Matheus Vescovi, Ikoma, Maura Rosane Valério, Lorand-Metze, Irene, Pereira, André Domingues, Farias, Danielle Leão Cordeiro de, Chauffaille, Maria de Lourdes Lopes Ferrari, Schaffel, Rony, Ribeiro, Eduardo Flávio Oliveira, Rocha, Talita Silveira da, Buccheri, Valeria, Vasconcelos, Yuri, Figueiredo, Vera Lúcia de Piratininga, Chiattone, Carlos Sérgio, Yamamoto, Mihoko
Format Journal Article
LanguageEnglish
Portuguese
Published Brazil Elsevier Editora Ltda 01.10.2016
Sociedade Brasileira de Hematologia e Hemoterapia
Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
Elsevier
Subjects
Chronic lymphocytic leukemia
Cytogenetics
HEMATOLOGY
Immunophenotyping
MEDICINE, RESEARCH & EXPERIMENTAL
Prognosis
Special
Staging
Cytogenetics
Immunophenotyping
Chronic lymphocytic leukemia
Prognosis
Staging
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Summary:Chronic lymphocytic leukemia is characterized by clonal proliferation and progressive accumulation of B-cell lymphocytes that typically express CD19+, CD5+ and CD23+. The lymphocytes usually infiltrate the bone marrow, peripheral blood, lymph nodes, and spleen. The diagnosis is established by immunophenotyping circulating B-lymphocytes, and prognosis is defined by two staging systems (Rai and Binet) established by physical examination and blood counts, as well as by several biological and genetic markers. In this update, we present the recommendations from the Brazilian Group of Chronic Lymphocytic Leukemia for the diagnosis and treatment of chronic lymphocytic leukemia. The following recommendations are based on an extensive literature review with the aim of contributing to more uniform patient care in Brazil and possibly in other countries with a similar social–economic profile.
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ISSN:1516-8484
1806-0870
1806-0870
DOI:10.1016/j.bjhh.2016.07.004