Dectin‐1 promotes fungicidal activity of human neutrophils
Human polymorphonuclear leukocytes (PMN) are a first line of defense against fungal infections. PMN express numerous pattern recognition receptors (PRR) that facilitate identification of invading microorganisms and ultimately promote resolution of disease. Dectin‐1 (β‐glucan receptor) is a PRR expre...
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| Published in | European Journal of Immunology Vol. 37; no. 2; pp. 467 - 478 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Weinheim
WILEY‐VCH Verlag
01.02.2007
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0014-2980 1521-4141 1365-2567 |
| DOI | 10.1002/eji.200636653 |
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| Abstract | Human polymorphonuclear leukocytes (PMN) are a first line of defense against fungal infections. PMN express numerous pattern recognition receptors (PRR) that facilitate identification of invading microorganisms and ultimately promote resolution of disease. Dectin‐1 (β‐glucan receptor) is a PRR expressed on several cell types and has been studied on monocytes and macrophages. However, the role played by dectin‐1 in the recognition and killing of fungi by PMN is unknown. We investigated the ability of dectin‐1 to mediate human PMN phagocytosis and fungicidal activity. Dectin‐1 was expressed on the surface of PMN from all subjects tested (n=29) and in an intracellular compartment that co‐sedimented with azurophilic granules in Percoll density gradients. Soluble β‐glucan and mAb GE2 (anti‐dectin‐1) inhibited binding and phagocytosis of zymosan by human PMN (e.g., ingestion was inhibited 40.1% by 30 min, p<0.001), and blocked reactive oxygen species production. Notably, soluble β‐glucan and GE2 inhibited phagocytosis and killing of Candida albicans by PMN (inhibition of killing was 54.8% for β‐glucan and 36.2% for GE2, p<0.01). Our results reveal a mechanism whereby PMN dectin‐1 plays a key role in the recognition and killing of fungal pathogens by the innate immune system. |
|---|---|
| AbstractList | Human polymorphonuclear leukocytes (PMN) are a first line of defense against fungal infections. PMN express numerous pattern recognition receptors (PRR) that facilitate identification of invading microorganisms and ultimately promote resolution of disease. Dectin‐1 (β‐glucan receptor) is a PRR expressed on several cell types and has been studied on monocytes and macrophages. However, the role played by dectin‐1 in the recognition and killing of fungi by PMN is unknown. We investigated the ability of dectin‐1 to mediate human PMN phagocytosis and fungicidal activity. Dectin‐1 was expressed on the surface of PMN from all subjects tested (
n
=29) and in an intracellular compartment that co‐sedimented with azurophilic granules in Percoll density gradients. Soluble β‐glucan and mAb GE2 (anti‐dectin‐1) inhibited binding and phagocytosis of zymosan by human PMN (
e.g
., ingestion was inhibited 40.1% by 30 min,
p
<0.001), and blocked reactive oxygen species production. Notably, soluble β‐glucan and GE2 inhibited phagocytosis and killing of
Candida albicans
by PMN (inhibition of killing was 54.8% for β‐glucan and 36.2% for GE2,
p
<0.01). Our results reveal a mechanism whereby PMN dectin‐1 plays a key role in the recognition and killing of fungal pathogens by the innate immune system. Human polymorphonuclear leukocytes (PMN) are a first line of defense against fungal infections. PMN express numerous pattern recognition receptors (PRR) that facilitate identification of invading microorganisms and ultimately promote resolution of disease. Dectin-1 (beta-glucan receptor) is a PRR expressed on several cell types and has been studied on monocytes and macrophages. However, the role played by dectin-1 in the recognition and killing of fungi by PMN is unknown. We investigated the ability of dectin-1 to mediate human PMN phagocytosis and fungicidal activity. Dectin-1 was expressed on the surface of PMN from all subjects tested (n=29) and in an intracellular compartment that co-sedimented with azurophilic granules in Percoll density gradients. Soluble beta-glucan and mAb GE2 (anti-dectin-1) inhibited binding and phagocytosis of zymosan by human PMN (e.g., ingestion was inhibited 40.1% by 30 min, p<0.001), and blocked reactive oxygen species production. Notably, soluble beta-glucan and GE2 inhibited phagocytosis and killing of Candida albicans by PMN (inhibition of killing was 54.8% for beta-glucan and 36.2% for GE2, p<0.01). Our results reveal a mechanism whereby PMN dectin-1 plays a key role in the recognition and killing of fungal pathogens by the innate immune system.Human polymorphonuclear leukocytes (PMN) are a first line of defense against fungal infections. PMN express numerous pattern recognition receptors (PRR) that facilitate identification of invading microorganisms and ultimately promote resolution of disease. Dectin-1 (beta-glucan receptor) is a PRR expressed on several cell types and has been studied on monocytes and macrophages. However, the role played by dectin-1 in the recognition and killing of fungi by PMN is unknown. We investigated the ability of dectin-1 to mediate human PMN phagocytosis and fungicidal activity. Dectin-1 was expressed on the surface of PMN from all subjects tested (n=29) and in an intracellular compartment that co-sedimented with azurophilic granules in Percoll density gradients. Soluble beta-glucan and mAb GE2 (anti-dectin-1) inhibited binding and phagocytosis of zymosan by human PMN (e.g., ingestion was inhibited 40.1% by 30 min, p<0.001), and blocked reactive oxygen species production. Notably, soluble beta-glucan and GE2 inhibited phagocytosis and killing of Candida albicans by PMN (inhibition of killing was 54.8% for beta-glucan and 36.2% for GE2, p<0.01). Our results reveal a mechanism whereby PMN dectin-1 plays a key role in the recognition and killing of fungal pathogens by the innate immune system. Human polymorphonuclear leukocytes (PMN) are a first line of defense against fungal infections. PMN express numerous pattern recognition receptors (PRR) that facilitate identification of invading microorganisms and ultimately promote resolution of disease. Dectin‐1 (β‐glucan receptor) is a PRR expressed on several cell types and has been studied on monocytes and macrophages. However, the role played by dectin‐1 in the recognition and killing of fungi by PMN is unknown. We investigated the ability of dectin‐1 to mediate human PMN phagocytosis and fungicidal activity. Dectin‐1 was expressed on the surface of PMN from all subjects tested (n=29) and in an intracellular compartment that co‐sedimented with azurophilic granules in Percoll density gradients. Soluble β‐glucan and mAb GE2 (anti‐dectin‐1) inhibited binding and phagocytosis of zymosan by human PMN (e.g., ingestion was inhibited 40.1% by 30 min, p<0.001), and blocked reactive oxygen species production. Notably, soluble β‐glucan and GE2 inhibited phagocytosis and killing of Candida albicans by PMN (inhibition of killing was 54.8% for β‐glucan and 36.2% for GE2, p<0.01). Our results reveal a mechanism whereby PMN dectin‐1 plays a key role in the recognition and killing of fungal pathogens by the innate immune system. Human polymorphonuclear leukocytes (PMN) are a first line of defense against fungal infections. PMN express numerous pattern recognition receptors (PRR) that facilitate identification of invading microorganisms and ultimately promote resolution of disease. Dectin-1 (beta-glucan receptor) is a PRR expressed on several cell types and has been studied on monocytes and macrophages. However, the role played by dectin-1 in the recognition and killing of fungi by PMN is unknown. We investigated the ability of dectin-1 to mediate human PMN phagocytosis and fungicidal activity. Dectin-1 was expressed on the surface of PMN from all subjects tested (n=29) and in an intracellular compartment that co-sedimented with azurophilic granules in Percoll density gradients. Soluble beta-glucan and mAb GE2 (anti-dectin-1) inhibited binding and phagocytosis of zymosan by human PMN (e.g., ingestion was inhibited 40.1% by 30 min, p<0.001), and blocked reactive oxygen species production. Notably, soluble beta-glucan and GE2 inhibited phagocytosis and killing of Candida albicans by PMN (inhibition of killing was 54.8% for beta-glucan and 36.2% for GE2, p<0.01). Our results reveal a mechanism whereby PMN dectin-1 plays a key role in the recognition and killing of fungal pathogens by the innate immune system. Human polymorphonuclear leukocytes (PMN) are a first line of defense against fungal infections. PMN express numerous pattern recognition receptors (PRR) that facilitate identification of invading microorganisms and ultimately promote resolution of disease. Dectin-1 (-glucan receptor) is a PRR expressed on several cell types and has been studied on monocytes and macrophages. However, the role played by dectin-1 in the recognition and killing of fungi by PMN is unknown. We investigated the ability of dectin-1 to mediate human PMN phagocytosis and fungicidal activity. Dectin-1 was expressed on the surface of PMN from all subjects tested (n=29) and in an intracellular compartment that co-sedimented with azurophilic granules in Percoll density gradients. Soluble -glucan and mAb GE2 (anti-dectin-1) inhibited binding and phagocytosis of zymosan by human PMN (e.g., ingestion was inhibited 40.1% by 30min, p<0.001), and blocked reactive oxygen species production. Notably, soluble -glucan and GE2 inhibited phagocytosis and killing of Candida albicans by PMN (inhibition of killing was 54.8% for -glucan and 36.2% for GE2, p<0.01). Our results reveal a mechanism whereby PMN dectin-1 plays a key role in the recognition and killing of fungal pathogens by the innate immune system. |
| Author | Kennedy, Adam D. Dorward, David W. Brown, Gordon D. Williams, David L. Willment, Janet A. DeLeo, Frank R. |
| Author_xml | – sequence: 1 givenname: Adam D. surname: Kennedy fullname: Kennedy, Adam D. – sequence: 2 givenname: Janet A. surname: Willment fullname: Willment, Janet A. – sequence: 3 givenname: David W. surname: Dorward fullname: Dorward, David W. – sequence: 4 givenname: David L. surname: Williams fullname: Williams, David L. – sequence: 5 givenname: Gordon D. surname: Brown fullname: Brown, Gordon D. – sequence: 6 givenname: Frank R. surname: DeLeo fullname: DeLeo, Frank R. email: fdeleo@niaid.nih.gov |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17230442$$D View this record in MEDLINE/PubMed |
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| Snippet | Human polymorphonuclear leukocytes (PMN) are a first line of defense against fungal infections. PMN express numerous pattern recognition receptors (PRR) that... |
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| SubjectTerms | Candida albicans Candida albicans - immunology Cell surface molecules Cytotoxicity, Immunologic Electrophoresis, Polyacrylamide Gel Flow Cytometry Fluorescent Antibody Technique Fungal Human Humans Immunoblotting Lectins, C-Type Membrane Proteins - immunology Microscopy, Confocal Microscopy, Electron, Scanning Microscopy, Electron, Transmission Nerve Tissue Proteins - immunology Neutrophils Neutrophils - immunology Neutrophils - microbiology Neutrophils - ultrastructure Phagocytosis Phagocytosis - immunology |
| Title | Dectin‐1 promotes fungicidal activity of human neutrophils |
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