Glycerol: a review of its pharmacology, pharmacokinetics, adverse reactions, and clinical use

• Published in: Pharmacotherapy Vol. 1; no. 2; p. 147
• Main Authors: Frank, M S, Nahata, M C, Hilty, M D
• Format: Journal Article
• Language: English
• Published: United States 10.09.1981
• Subjects: Animals; Brain Injuries - drug therapy; Brain Neoplasms - drug therapy; Cerebrovascular Disorders - drug therapy; Dehydration - chemically induced; Encephalitis - drug therapy; Glycerol - adverse effects; Glycerol - metabolism; Glycerol - pharmacology; Glycerol - therapeutic use; Humans; Kinetics; Meningitis - drug therapy; Pseudotumor Cerebri - drug therapy; Reye Syndrome - drug therapy; Water-Electrolyte Balance - drug effects

Glycerol is a potent osmotic dehydrating agent with additional effects on brain metabolism. In doses of 0.25-2.0 g/kg glycerol decreases intracranial pressure in numerous disease states, including Reye's syndrome, stroke, encephalitis, meningitis, pseudotumor cerebri, central nervous system tum...