The identification of myogenic cells in skeletal muscle, with emphasis on the use of tritiated thymidine autoradiography and desmin antibodies

• Published in: Journal of anatomy Vol. 192; no. 2; pp. 161 - 171
• Main Authors: LAWSON‐SMITH, MATTHEW J., McGEACHIE, JOHN K.
• Format: Journal Article
• Language: English
• Published: Edinburgh, UK Blackwell Science Ltd 01.02.1998
• Subjects: Animals; Antibodies, Monoclonal; Autoradiography; Biomarkers - analysis; bromodeoxyuridine; Cell Division; cell markers; Desmin - analysis; Desmin - immunology; DNA - analysis; Humans; Immunohistochemistry; Mice; Muscle, Skeletal - chemistry; Muscle, Skeletal - cytology; Muscle, Skeletal - physiology; myoblasts; MyoD; Myogenesis; myogenin; proliferating cell nuclear antigen; Regeneration; satellite cells; Stem Cells - cytology

The identification of myogenic precursor cells (mpc) is a key factor in determining the early events in the myogenesis and regeneration of skeletal muscle. Although satellite cells have long been established as the providers of myoblastic cells, very little is really known (apart from their anatomic...