Acetaminophen usage patterns and concentrations of glutathione and gamma-glutamyl transferase in alcoholic subjects

• Published in: Pharmacotherapy Vol. 27; no. 11; p. 1473
• Main Authors: Seifert, Charles F, Anderson, Douglas C
• Format: Journal Article
• Language: English
• Published: United States 01.11.2007
• Subjects: Acetaminophen - administration & dosage; Acetaminophen - adverse effects; Adult; Alcohol Drinking - adverse effects; Alcoholism - complications; Analgesics, Non-Narcotic - administration & dosage; Analgesics, Non-Narcotic - adverse effects; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Cohort Studies; Community Health Centers; Dose-Response Relationship, Drug; Female; gamma-Glutamyltransferase - blood; Glutathione - blood; Humans; Liver - pathology; Liver Diseases - epidemiology; Liver Function Tests; Male; Middle Aged; Prospective Studies; Substance-Related Disorders

To determine if subjects with chronic alcoholism are predisposed to acetaminophen-induced hepatotoxicity, and to determine the contributing factors. Prospective cohort study. Community-based crisis intervention center. One hundred eighty-eight subjects who answered "yes" to at least one of...