Endothelial Cell Metabolism in Normal and Diseased Vasculature

• Published in: Circulation research Vol. 116; no. 7; pp. 1231 - 1244
• Main Authors: Eelen, Guy, de Zeeuw, Pauline, Simons, Michael, Carmeliet, Peter
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 27.03.2015
• Subjects: Amino Acids - metabolism; Atherosclerosis - metabolism; Atherosclerosis - pathology; Cell Movement; Diabetic Angiopathies - metabolism; Endothelial Cells - classification; Endothelial Cells - metabolism; Endothelial Cells - pathology; Endothelium, Vascular - metabolism; Energy Metabolism; Fatty Acids - metabolism; Glucose - metabolism; Glycation End Products, Advanced - metabolism; Humans; Morphogenesis; Neoplasms - blood supply; Neovascularization, Pathologic - metabolism; Neovascularization, Physiologic - physiology; Nitric Oxide - metabolism; Oxidative Stress; Reactive Oxygen Species - metabolism; Stromal Cells - metabolism; Translational Research, Biomedical; Tumor Microenvironment; Vascular Diseases - metabolism; Vascular Diseases - pathology; atherosclerosis; cancer; diabetes mellitus; endothelial metabolism; angiogenesis

Higher organisms rely on a closed cardiovascular circulatory system with blood vessels supplying vital nutrients and oxygen to distant tissues. Not surprisingly, vascular pathologies rank among the most life-threatening diseases. At the crux of most of these vascular pathologies are (dysfunctional)...