Mitochondria-rough-ER contacts in the liver regulate systemic lipid homeostasis

• Published in: Cell reports (Cambridge) Vol. 34; no. 11; p. 108873
• Main Authors: Anastasia, Irene, Ilacqua, Nicolò, Raimondi, Andrea, Lemieux, Philippe, Ghandehari-Alavijeh, Rana, Faure, Guilhem, Mekhedov, Sergei L., Williams, Kevin J., Caicci, Federico, Valle, Giorgio, Giacomello, Marta, Quiroga, Ariel D., Lehner, Richard, Miksis, Michael J., Toth, Katalin, de Aguiar Vallim, Thomas Q., Koonin, Eugene V., Scorrano, Luca, Pellegrini, Luca
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 16.03.2021
• Subjects: Animals; endoplasmic reticulum; Endoplasmic Reticulum - metabolism; Endoplasmic Reticulum - ultrastructure; Enterocytes - metabolism; Gene Silencing; Hepatocytes - metabolism; Homeostasis; Imaging, Three-Dimensional; inter-organelle contact; Intestine, Small - cytology; Lipids - chemistry; lipoprotein; Lipoproteins, VLDL - biosynthesis; Liver - metabolism; Male; MAM; Metabolomics; Mice; Mice, Inbred C57BL; mitochondria; Mitochondria - metabolism; Mitochondria - ultrastructure; Mitochondrial Membranes - metabolism; MUP; Phospholipids - biosynthesis; Proteins - metabolism; Rrbp1; VLDL; wrappER; lipoprotein; mitochondria; VLDL; MAM; MUP; liver metabolism; wrappER; Rrbp1; endoplasmic reticulum; inter-organelle contact

Contacts between organelles create microdomains that play major roles in regulating key intracellular activities and signaling pathways, but whether they also regulate systemic functions remains unknown. Here, we report the ultrastructural organization and dynamics of the inter-organellar contact es...