XCR1+ DCs are critical for T cell-mediated immunotherapy of chronic viral infections

• Published in: Cell reports (Cambridge) Vol. 42; no. 2; p. 112123
• Main Authors: Domenjo-Vila, Eva, Casella, Valentina, Iwabuchi, Ryutaro, Fossum, Even, Pedragosa, Mireia, Castellví, Quim, Cebollada Rica, Paula, Kaisho, Tsuneyasu, Terahara, Kazutaka, Bocharov, Gennady, Argilaguet, Jordi, Meyerhans, Andreas
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 28.02.2023; Elsevier
• Subjects: anti-PD-L1; chronic infection; CP: Immunology; Flt3L; immunotherapy; LCMV; SIRPɑ+ DCs; T cell exhaustion; therapeutic vaccination; XCR1+ DCs; anti-PD-L1; CP: Immunology; LCMV; chronic infection; therapeutic vaccination; immunotherapy; T cell exhaustion; Flt3L; XCR1+ DCs; SIRPɑ+ DCs

The contribution of cross-presenting XCR1+ dendritic cells (DCs) and SIRPα+ DCs in maintaining T cell function during exhaustion and immunotherapeutic interventions of chronic infections remains poorly characterized. Using the mouse model of chronic LCMV infection, we found that XCR1+ DCs are more r...