Glyco-engineering of biotherapeutic proteins in plants

Many therapeutic glycoproteins have been successfully generated in plants. Plants have advantages regarding practical and economic concerns, and safety of protein production over other existing systems. However, plants are not ideal expression systems for the production of biopharmaceutical proteins...

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Published inMolecules and cells Vol. 25; no. 4; pp. 494 - 503
Main Authors Ko, K.S. (Wonkwang University, Iksan, Republic of Korea), E-mail: ksko@wku.ac.kr, Ahn, M.H. (Wonkwang University, Iksan, Republic of Korea), Song, M.R. (Wonkwang University, Iksan, Republic of Korea), Choo, Y.K. (Wonkwang University, Iksan, Republic of Korea), Kim, H.S. (Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea), Ko, Kinarm (Max Planck Institute for Molecular Biomedicine, Department of Cell and Developmental Biology, Munster, Germany), Joung, H. (Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea)
Format Journal Article
LanguageEnglish
Published United States 한국분자세포생물학회 30.06.2008
Subjects
Biopharmaceutics - methods
Endoplasmic Reticulum - metabolism
GLICOPROTEINAS
GLYCOPROTEINE
GLYCOPROTEINS
Glycoproteins - biosynthesis
Glycoproteins - genetics
Glycosylation
Golgi Apparatus - metabolism
Humans
molecular biopharming
monoclonal antibody
PLANTAS TRANSGENICAS
PLANTE TRANSGENIQUE
Plants, Genetically Modified - cytology
Plants, Genetically Modified - enzymology
Plants, Genetically Modified - genetics
Protein Engineering
Protein Transport - genetics
PROTEINAS RECOMBINANTES
PROTEINE RECOMBINANTE
RECOMBINANT PROTEINS
Recombinant Proteins - genetics
Recombinant Proteins - metabolism
Recombinant Proteins - therapeutic use
TRANSGENIC PLANTS
생물학
Online AccessGet full text

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Abstract Many therapeutic glycoproteins have been successfully generated in plants. Plants have advantages regarding practical and economic concerns, and safety of protein production over other existing systems. However, plants are not ideal expression systems for the production of biopharmaceutical proteins, due to the fact that they are incapable of the authentic human N-glycosylation process. The majority of therapeutic proteins are glycoproteins which harbor N-glycans, which are often essential for their stability, folding, and biological activity. Thus, several glyco-engineering strategies have emerged for the tailor-making of N-glycosylation in plants, including glycoprotein subcellular targeting, the inhibition of plant specific glycosyltranferases, or the addition of human specific glycosyltransferases. This article focuses on plant N-glycosylation structure, glycosylation variation in plant cell, plant expression system of glycoproteins, and impact of glycosylation on immunological function. Furthermore, plant glyco-engineering techniques currently being developed to overcome the limitations of plant expression systems in the production of therapeutic glycoproteins will be discussed in this review.
AbstractList Many therapeutic glycoproteins have been successfully generated in plants. Plants have advantages regarding practical and economic concerns, and safety of protein production over other existing systems. However, plants are not ideal expression systems for the production of biopharmaceutical proteins, due to the fact that they are incapable of the authentic human N-glycosylation process. The majority of therapeutic proteins are glycoproteins which harbor N-glycans, which are often essential for their stability, folding, and biological activity. Thus, several glyco-engineering strategies have emerged for the tailor-making of N-glycosylation in plants, including glycoprotein subcellular targeting, the inhibition of plant specific glycosyltranferases, or the addition of human specific glycosyltransferases. This article focuses on plant N-glycosylation structure, glycosylation variation in plant cell, plant expression system of glycoproteins, and impact of glycosylation on immunological function. Furthermore, plant glyco-engineering techniques currently being developed to overcome the limitations of plant expression systems in the production of therapeutic glycoproteins will be discussed in this review.
Many therapeutic glycoproteins have been successfully generated in plants. Plants have advantages regarding practical and economic concerns, and safety of protein production over other existing systems. However, plants are not ideal expression systems for the production of biopharmaceutical proteins, due to the fact that they are incapable of the authentic human N-glycosylation process. The majority of therapeutic proteins are glycoproteins which harbor N-glycans, which are often essential for their stability, folding, and biological activity. Thus, several glyco-engineering strategies have emerged for the tailor-making of N-glycosylation in plants, including glycoprotein subcellular targeting, the inhibition of plant specific glycosyltranferases, or the addition of human specific glycosyltransferases. This article focuses on plant N-glycosylation structure, glycosylation variation in plant cell, plant expression system of glycoproteins, and impact of glycosylation on immunological function. Furthermore, plant glycoengineering techniques currently being developed to overcome the limitations of plant expression systems in the production of therapeutic glycoproteins will be discussed in this review. KCI Citation Count: 23
Author Joung, H. (Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea)
Ko, K.S. (Wonkwang University, Iksan, Republic of Korea), E-mail: ksko@wku.ac.kr
Ahn, M.H. (Wonkwang University, Iksan, Republic of Korea)
Song, M.R. (Wonkwang University, Iksan, Republic of Korea)
Choo, Y.K. (Wonkwang University, Iksan, Republic of Korea)
Kim, H.S. (Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea)
Ko, Kinarm (Max Planck Institute for Molecular Biomedicine, Department of Cell and Developmental Biology, Munster, Germany)
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Snippet Many therapeutic glycoproteins have been successfully generated in plants. Plants have advantages regarding practical and economic concerns, and safety of...
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SubjectTerms Biopharmaceutics - methods
Endoplasmic Reticulum - metabolism
GLICOPROTEINAS
GLYCOPROTEINE
GLYCOPROTEINS
Glycoproteins - biosynthesis
Glycoproteins - genetics
Glycosylation
Golgi Apparatus - metabolism
Humans
molecular biopharming
monoclonal antibody
PLANTAS TRANSGENICAS
PLANTE TRANSGENIQUE
Plants, Genetically Modified - cytology
Plants, Genetically Modified - enzymology
Plants, Genetically Modified - genetics
Protein Engineering
Protein Transport - genetics
PROTEINAS RECOMBINANTES
PROTEINE RECOMBINANTE
RECOMBINANT PROTEINS
Recombinant Proteins - genetics
Recombinant Proteins - metabolism
Recombinant Proteins - therapeutic use
TRANSGENIC PLANTS
생물학
Title Glyco-engineering of biotherapeutic proteins in plants
URI https://www.ncbi.nlm.nih.gov/pubmed/18443408
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Volume 25
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