Myeloma bone disease: from biology findings to treatment approaches

• Published in: Blood Vol. 133; no. 14; pp. 1534 - 1539
• Main Authors: Terpos, Evangelos, Ntanasis-Stathopoulos, Ioannis, Dimopoulos, Meletios A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 04.04.2019
• Subjects: Bone Diseases - drug therapy; Bone Diseases - etiology; Denosumab - therapeutic use; Humans; Multiple Myeloma - complications; Multiple Myeloma - drug therapy; Osteocytes - pathology

Bone disease is a cardinal complication of multiple myeloma that affects quality of life and survival. Osteocytes have emerged as key players in the development of myeloma-related bone disease. Along with other factors, they participate in increased osteoclast activity, decreased osteoblast function...