The early neutrophil-committed progenitors aberrantly differentiate into immunoregulatory monocytes during emergency myelopoiesis

• Published in: Cell reports (Cambridge) Vol. 42; no. 3; p. 112165
• Main Authors: Ikeda, Naoki, Kubota, Hiroaki, Suzuki, Risa, Morita, Mitsuki, Yoshimura, Ayana, Osada, Yuya, Kishida, Keigo, Kitamura, Daiki, Iwata, Ayaka, Yotsumoto, Satoshi, Kurotaki, Daisuke, Nishimura, Koutarou, Nishiyama, Akira, Tamura, Tomohiko, Kamatani, Takashi, Tsunoda, Tatsuhiko, Murakawa, Miyako, Asahina, Yasuhiro, Hayashi, Yoshihiro, Harada, Hironori, Harada, Yuka, Yokota, Asumi, Hirai, Hideyo, Seki, Takao, Kuwahara, Makoto, Yamashita, Masakatsu, Shichino, Shigeyuki, Tanaka, Masato, Asano, Kenichi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 28.03.2023; Elsevier
• Subjects: Animals; Cell Differentiation; CP: Immunology; CXCR1; demand-adapted myelopoiesis; emergency myelopoiesis; G-CSF; Granulocyte Colony-Stimulating Factor; Humans; machine learning; Mice; monocyte; Monocytes - physiology; Myelopoiesis; neutrophil-like monocyte; Neutrophils; ontogeny; Ym1; demand-adapted myelopoiesis; CP: Immunology; emergency myelopoiesis; CXCR1; monocyte; neutrophil-like monocyte; Ym1; machine learning; G-CSF; ontogeny

Inflammatory stimuli cause a state of emergency myelopoiesis leading to neutrophil-like monocyte expansion. However, their function, the committed precursors, or growth factors remain elusive. In this study we find that Ym1+Ly6Chi monocytes, an immunoregulatory entity of neutrophil-like monocytes, a...