Plasma exosomal miR-223 expression regulates inflammatory responses during cardiac surgery with cardiopulmonary bypass

• Published in: Scientific reports Vol. 7; no. 1; pp. 10807 - 11
• Main Authors: Poon, Kin-Shing, Palanisamy, Kalaiselvi, Chang, Shih-Sheng, Sun, Kuo-Ting, Chen, Kuen-Bao, Li, Ping-Chun, Lin, Tso-Chou, Li, Chi-Yuan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.09.2017; Nature Publishing Group
• Subjects: 692/4019/592; 692/700/459/1748; Cardiopulmonary Bypass - adverse effects; Cell signaling; Cytokines - blood; Exosomes; Exosomes - metabolism; Gene Expression Regulation; Heart; Heart diseases; Heart surgery; Homeostasis; Humanities and Social Sciences; Humans; Inflammation; Inflammation - pathology; Interleukin 6; Interleukin 8; MicroRNAs - blood; miRNA; Monocytes; multidisciplinary; Plasma - chemistry; Science; Science (multidisciplinary); Thoracic Surgery; Time Factors; Tumor necrosis factor-α

Cardiopulmonary bypass (CPB) induces inflammatory responses, and effective endogenous homeostasis is important for preventing systemic inflammation. We assessed whether plasma exosomal microRNAs in patients undergoing cardiac surgery with CPB are involved in the regulation of inflammatory responses....